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Adoptive immunotherapy of disseminated malignancies

Role of alien histocompatibility antigens on cancer cells and effectiveness of cells from alloimmunized donors

  • Published:
Ricerca in clinica e in laboratorio

Summary

The potential role of genetically inappropriate histocompatibility antigens on tumor cells as immunogens and targets for immunotherapy is reviewed. The evidence for immunologic mediation of tumor resistance following individual and pool alloimmunization bothin vivo in murine andin vitro in murine and human systems is presented. The antileukemic reaction which follows transplantation of cells from alloimmunized MHC-compatible donors to mice bearing disseminated AKR leukemia is discussed in terms of antigen specificity, effector cell mechanisms and as an immunotherapeutic model. Possible advantages of utilizing cells from MHC-compatible allogeneic donors, rather than from tumor-bearing patients, for immunotherapy of human tumors are discussed. Although many investigators are assessing the significance of alien histocompatibility antigens on cancer cells and the mechanism by which alloimmunization induces antitumor immunity, it remains to be determined whether these efforts will result in an important advance in the treatment of patients with disseminated malignancies.

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Authors and Affiliations

  1. Department of Medicine, University of Wisconsin Medical School, Milwaukee Clinical Campus, Wisconsin, USA

    Laurence D. Tempelis

  2. Section of Hematology/Oncology, Mount Sinai Medical Center, New York, USA

    Laurence D. Tempelis

  3. The Transplantation Institute, Academy of Medicine, Warsaw, Poland

    Maria R. Wasik (Visiting Scientist from)

  4. May and Sigmund Winter Research Laboratory, Mount Sinai Medical Center, Milwaukee, 950 North Twelfth Street, P.O. Box 342, 53201, Milwaukee, Wis., USA

    Mortimer M. Bortin

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This work was supported by grants CA-20484 and CA-28738 from the US National Cancer Institute, USDHSS and grants from the Briggs and Stratton Corporation Foundation, Evan and Marion Helfaer Foundation, Kearney and Trecker Foundation, Milheim Foundation, Miller Foundation, Modine manufacturing Company, Elsa U. Pardee Foundation and the Rexnord Foundation.

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Tempelis, L.D., Wasik, M.R. & Bortin, M.M. Adoptive immunotherapy of disseminated malignancies. La Ricerca Clin. Lab. 13, 163–182 (1983). https://doi.org/10.1007/BF02904832

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