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An improved coupling reaction for the preparation of pyridylethynyl benzonitrile compounds

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Chinese Science Bulletin

Abstract

An improved coupling reaction between aromatic ring and acetylene triple bond catalyzed by palladium (0) catalyses for the preparation of pyridylethynyl benzonitrile compounds is described. Efforts were made to improve the reaction by changing different reaction conditions and it was found that the solvent is one important factor in this situation.

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Authors and Affiliations

  1. Department of Chemistry, University of Science & Technology of China, 230026, Hefei, China

    Zhiyong Wang, Chao Jiang & Qingxiang Guo

  2. Deparment of Chemistry, Brandeis University, MA02454, Waltham, USA

    Wenbin Lin

Authors
  1. Zhiyong Wang
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  2. Wenbin Lin
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  3. Chao Jiang
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  4. Qingxiang Guo
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Correspondence to Zhiyong Wang.

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Wang, Z., Lin, W., Jiang, C. et al. An improved coupling reaction for the preparation of pyridylethynyl benzonitrile compounds. Chin.Sci.Bull. 46, 1606–1608 (2001). https://doi.org/10.1007/BF02900616

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  • DOI: https://doi.org/10.1007/BF02900616

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