Summary
Studies of human hematologic malignancies have provided sufficient data not only for the identification of nonrandom abnormalities of whole chromosomes, but also for determination of the specific chromosome regions involved. In clonal aberrations leading to an excess of chromosome No. 1, or a partial excess of No. 1, trisomy for bands 1q25 to 1q32 was noted in the myeloid cells obtained from every one of 35 patients who had various disorders, such as acute leukemia, polycythemia vera, or myelofibrosis. Similar chromosome changes were a consistent finding in various solid tumors as well. This rearrangement was not the result of a particularly fragile site in that region of the chromosome, since the break points in reciprocal translocations that involve No. 1 occurred almost exclusively in the short arm.
The nonrandom chromosome changes found in neoplastic cells can now be correlated with the gene loci on these chromosomes or chromosome segments as an attempt is made to identify specific genes that might be related to malignancy.
Similar content being viewed by others
References
Atkin, N.B., Baker, M.C.: Chromosome 1 in cervical carcinoma. Lancetii, 984 (1977)
Atkin, N.B., Pickhall, V.J.: Chromosome 1 in 14 ovarian cancers. Human Genet.38, 25–33 (1977)
Ayraud, N., Lambert, J.-C., Hufferman-Tribollet, K., Basteris, B.: Etude cytogénétique comparative de sept carcinomes d’origine mammaire. Ann. Génét.20, 171–177 (1977)
Azumi, J.-I., Sachs, L.: Chromosome mapping of the genes that control differentiation and malignancy in myeloid leukemic cells. Proc. Natl. Acad. Sci. USA74, 253–257 (1977)
Codish, S.D., Paul, B.: Reversible appearance of a specific chromosome which suppresses malignancy. Nature252, 610–612 (1974)
Cruciger, Q.V. Jones, Pathak, S., Cailleau, R.: Human breast carcinomas: Marker chromosomes involving 1q in seven cases. Cytogenet. Cell Genet.17, 231–235 (1976)
Cruciger, Q., Pathak, S., Barker, P., Cailleau, R., Eckles, N., Blumenschein, G.: Consistent translocation of 1q chromosome in metastatic breast cancer tissue and cell lines — clinical correlations. AFCR Oncology (abstract), 433A (1978)
Fialkow, P.J., Martin, G.M., Klein, G.: Evidence for a clonal origin of head and neck tumors. Int. J. Cancer9, 133–142 (1970)
Gahrton, G., Lindsten, J., Zech, L.: Trisomy 8 in acute myeloblastic leukemia and sideroachrestic anemia. Blood43, 837–840 (1974)
Gahrton, G., Friberg, K., Zech, L., Lindsten, J.: Duplication of part of chromosome no. 1 in myeloproliferative diseases. Lanceti, 96–97 (1978)
Kakati, S., Song, S.Y., Sandberg, A.A.: Chromosomes and causation of human cancer and leukemia. XXII. Karyotypic changes in malignant melanoma. Cancer40, 1173–1181 (1977)
Kovacs, G.: Abnormalities of chromosome no. 1 in haematological malignancies. Lanceti, 554–555 (1978)
Klein, G., Bregula, U., Wiener, F., Harris, H.: The analysis of malignancy by cell fusion. I. Hybrids between tumor cells and L cell derivatives. J. Cell Sci.8, 659–672 (1971)
Linder, D., Gartler, S.M.: Glucose-6-phosphate dehydrogenase mosaicism: Utilization as a cell marker in the study of leiomyomas. Science150, 67–69 (1965)
McKusick, V.A., Ruddle, F.H.: The status of the gene map of the human chromosomes. Science196, 390–405 (1977)
Mitelman, F., Levan, G.: Clustering of aberrations to specific chromosomes in human neoplasms. II. A survey of 287 neoplasms. Hereditas82, 167–174 (1976)
Nowell, P.C.: The clonal evolution of tumor cell populations. Science194, 23–28 (1976)
Rowley, J.D.: Nonrandom chromosomal abnormalities in hematologic disorders of man. Proc. Natl. Acad. Sci. USA72, 152–156 (1975)
Rowley, J.D., Potter, D.: Chromosomal banding patterns in acute nonlymphocytic leukemia. Blood47, 705–721 (1976)
Rowley, J.D.: Nonrandom chromosomal changes in human malignant cells. In: Molecular human genetics (ICN*UCLA Symposia on Molecular and Cellular Biology, Vol. II) (R.S. Sparkes, D. Comings, C.F. Fox, eds.) pp. 457–472. New York: Academic Press 1977a
Rowley, J.B.: Mapping of human chromosomal regions related to neoplasia: Evidence from chromosomes 1 and 17. Proc. Natl. Acad. Sci. USA74, 5729–5733 (1977b)
Yamada, K., Furusawa, S.: Preferential involvement of chromosomes No. 8 and No. 21 in acute leukemia and preleukemia. Blood47, 679–686 (1976)
Yamamoto, T., Hayashi, M., Rabinowitz, Z., Sachs, L.: Chromosomal control of malignancy in tumors from cells transformed by polyoma virus. Int. J. Cancer11, 555–566 (1973)
Author information
Authors and Affiliations
Additional information
Operated by The University of Chicago for the U.S. Department of Energy under Contract No. EY-76-C-02-0069. Research supported by a grant from The National Cancer Institute (CA 16910) and the Otho S.A. Sprague Foundation
Rights and permissions
About this article
Cite this article
Rowley, J.D. Abnormalities of chromosome No. 1: Significance in malignant transformation. Virchows Arch. B Cell Path. 29, 139–144 (1978). https://doi.org/10.1007/BF02899347
Issue Date:
DOI: https://doi.org/10.1007/BF02899347