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Chromosomes 1 in 14 ovarian cancers

Heterochromatin variants and structural changes

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Summary

Structurally rearranged chromosomes 1 were found in 9 out of 14 ovarian carcinomas and may also have been present in three others. In the remaining two, pericentric inversions involving the heterochromatic regions of chromosomes 1 were seen, and were also identified in one of the chromosomes 1 in the patient's normal cells (lymphocytes). Altogether, heterochromatin variants (variation in size and/or the presence of a pericentric inversion) were seen in the tumour cells of eight cases, and one or both types of variation were identified in the normal cells of six of these.

The possibility of an association between the presence of chromosome 1 heterochromatin variants as a constitutional anomaly, a liability to ovarian (and perhaps other forms of) cancer and structural changes involving the chromosomes 1 in the tumour cells is considered.

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Author notes

  1. V. J. Pickthall

    Present address: Department of Cytogenetics and Immunology, Royal Marsden Hospital, Fulham Road, SW3, London, UK

Authors and Affiliations

  1. Department of Cancer Research, Mount Vernon Hospital, HA6 2RN, Northwood, Middx., UK

    N. B. Atkin & V. J. Pickthall

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  1. N. B. Atkin
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  2. V. J. Pickthall
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Atkin, N.B., Pickthall, V.J. Chromosomes 1 in 14 ovarian cancers. Hum Genet 38, 25–33 (1977). https://doi.org/10.1007/BF00295804

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  • DOI: https://doi.org/10.1007/BF00295804

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