Summary
Chromosome studies were performed on malignant cells obtained from 22 patients with non-Hodgkin lymphomas. A marker chromosome resulting from a translocation that affected the long arm of No. 14 (14q +) was the single most frequent abnormality and was noted in 14 of these patients. The frequency of the 14q+ marker chromosome varied with the type of lymphoma as defined by Rappaport. When the Lukes and Collins classification was used, the 14q+ marker was consistently associated with lymphomas having a clone of large noncleaved cells, small cleaved cells, and small noncleaved cells, but was absent in lymphomas composed of a clone of large cleaved cells and small lymphocytes. The findings suggest that, in certain groups of lymphoid malignancies, cells with a 14q translocation have a proliferative advantage compared with cells having other chromosome rearrangements, and that these malignant cells could be derived from a common progenitor.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Caspersson, T., Zech, L., Johansson, C.: Differential banding of alkylating fluorochromes in human chromosomes. Exp. Cell Res.60, 315–319 (1970)
Fleischman, E.W., Prigogina, E.L.: Karyotypic peculiarities of malignant lymphomas. Humangenetik35, 269–279 (1977)
Fukuhara, S., Shirakawa, S., Uchino, H.: Specific marker chromosome 14 in malignant lymphomas. Nature (Lond.)259, 210–211 (1976)
Fukuhara, S., Rowley, J.D.: Chromosome 14 translocations in non-Burkitt lymphomas. Int. J. Cancer22, 14–21 (1978)
Fukuhara, S., Rowley, J.D., Variakojis, D.: Banding studies of chromosomes in a patient with mycosis fungoides. Cancer (in press)
Fukuhara, S., Rowley, J.D., Variakojis, D., Sweet, D.L.: Banding studies on chromosomes in diffuse “histiocytic” lymphomas: Correlation of 14q+ marker chromosome with cytology. Blood (in press) (1978)
Lennert, K., Stein, H., Kaiserling, E.: Cytological and functional criteria for the classification of malignant lymphomas. Br. J. Cancer (Suppl. 2)31, 29–43 (1975)
Liang, W., Rowley, J.D.: 14q+ marker chromosomes in multiple myeloma and plasma-cell leukemia. LancetI, 96 (1978)
Lukes, R.J., Collins, R.D.: New approaches to the classification of the lymphomata. Br. J. Cancer (Suppl. 2)31, 1–28 (1975)
Manolov, G., Manolova, Y.: Marker band in one chromosome 14 from Burkitt lymphomas. Nature (Lond.)237, 33–34 (1972)
Mark, J.: Histiocytic lymphomas with the marker chromosome 14q +. Hereditas81, 289–292 (1975)
Mark, J., Ekedahl, C., Hagman, A.: Origin of the translocated segment of the 14q+ marker in non-Burkitt lymphomas. Humangenetik36, 277–282 (1977)
McCaw, B.K., Hecht, F., Harnden, D.G., Teplitz, R.L.: Somatic rearrangement of chromosome 14 in human lymphocytes. Proc. Nat. Acad. Sci.72, 2071–2075 (1975)
Oshimura, M., Freeman, A.T., Sandberg, A.A.: Chromosomes and causation of human cancer and leukemia. XXVI. Banding studies in acute lymphoblastic leukemia (ALL). Cancer40, 1161–1172 (1977)
Paris Conference (1971): Standardization in human chromosomes. Birth Defects8, (1972)
Stefos, K., Arrighi, F.E.: Heterochromatic nature of W chromosome in birds. Exp. Cell Res.68, 228–231 (1971)
Verma, R.S., Lubs, H.A.: A simple R-banding technique. Am. J. Hum. Genet.27, 110–117 (1975)
Yamada, K., Yoshioka, M., Oami, H.: A 14q+ marker and a late replicating chromosome #22 in a brain tumor. J. Natl. Cancer Inst.59, 1193–1195 (1977)
Zech, L., Haglund, U., Nilsson, K., Klein, G.: Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas. Int. J. Cancer17, 47–56 (1976)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fukuhara, S. Significance of 14q translocations in non-Hodgkin lymphomas. Virchows Arch. B Cell Path. 29, 99–106 (1978). https://doi.org/10.1007/BF02899342
Issue Date:
DOI: https://doi.org/10.1007/BF02899342