Summary
Karyotypes of 30 malignant lymphomas were studied with the aid of G-banding. Frequent occurrence of rearranged chromosomes 14 and 11 was noted. In several tumors, identical acrocentric markers, appearing after translocation of the long arm of chromosome 11 on the long arm of chromosome 14, were revealed. Other common karyotype abnormalities in lymphomas were trisomy 3 and trisomy 18. The chromosomes preferentially involved in karyotype abnormalities of the malignant lymphomas are mostly not altered in other hemoblastoses.
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Bochkov, N. P., Lopuchin, J. M., Kuleshov, N. P., Kovalchuk, L. V.: Cytogenetic study of patients with ataxia-telangiectasia. Humangenetik 24, 115–128 (1974)
Fleischmann, T., Häkansson, C. H., Levan, A.: Fluorescent marker chromosomes in malignant lymphomas. Hereditas 69, 311–314 (1971)
Fleischman, E. W., Prigogina, E. L., Platonova, G. M., Chudina, A. P., Kruglova, G. V., Kaverzneva, M. M.: Comparative chromosome characteristics of reticulosarcomas and Hodgkin's disease. Neoplasma 21, 51–61 (1974)
Fleischman, E. W., Prigogina, E. L.: G-banding in cytogenetic study of hemoblastoses. Humangenetik 26, 335–342 (1975)
Gahrton, G., Lindsten, J., Zech, L.: Involvement of chromosomes 8, 19 and 22 in Ph' positive and Ph' negative chronic myelocytic leukemia in chronic or blastic stage. Acta medica Scand. 196, 355–360 (1974)
Hayashi, K., Schmid, W.: Tandem duplication q14 by end to end chromosome fusions in ataxiatelangiectasia (AT). Clinical and cytogenetics findings in 5 patients. Humangenetik 30, 135–141 (1975)
Jarvis, J. E., Ball, G., Rickinson, A. B., Epstein, M. A.: Cytogenetics studies on human lymphoblastoid cell lines from Burkitt's lymphoma and other sources. Int. J. Cancer 14, 716–721 (1974)
Lawler, S. D., Reeves, B. R., Hamlin, J. M. E.: A comparison of cytogenetic and histopathology in the malignant lymphomata. Br. J. Cancer 31, 162–167 (1975)
Levan, A.: Chromosome patterns in tumors. In: Chromosome identification technique and application in biology and medicine, Nobel Symposia, T. Caspersson and L. Zech, eds., pp. 217–229. Stockholm, New York, London 1973
Levan, G., Mitelman, F.: Clustering of aberrations to specific chromosomes in human neoplasms. Hereditas 79, 156–160 (1975)
Mark, J., Levan, G., Mitelman, F.: Identification by fluorescence of the G chromosome lost in human meningeomas. Hereditas 71, 163–168 (1972)
Mark, J.: Histiocytic lymphomas with the marker chromosome 14q+. Hereditas 81, 289–292 (1975)
Manolov, G., Manolova, J.: Marker band in one chromsome 14 from Burkitt's lymphomas. Nature 237, 33–34 (1972)
McCaw, K. B., Hecht, F., Harnden, D. G., Teplitz, R. L.: Somatic rearrangement of chromosome 14 in human lymphocytes. Proc. Nat. Acad. Sci. USA 72, 2071–2075 (1975)
Nilsson, K., Ponten, J.: Classification and biological nature of established human hematopoietic cell lines. Int. J. Cancer 15, 321–341 (1975)
Oxford, J. M., Harnden, D. G., Parrington, J. M., Delhanty, J. D. A.: Specific chromosome aberrations in ataxia-telangiectasia. J. Med. Genetics 12, 251–260 (1975)
Paris Conference: Standardization in Human Cytogenetics. Birth Defects: Original Article Series, VIII, 7 (1972)
Philip, P.: Trisomy 8 in acute myeloid leukemia. Scand. J. Haematol. 14, 140–147 (1975a)
Philip, P.: Marker chromosome 14q+ in multiple myeloma. Hereditas 80, 155–156 (1975b)
Prigogina, E. L., Fleischman, E. W.: Certain patterns of karyotype evolution in chronic myelogeneous leukemia. Humangenetik 30, 109–119 (1975a)
Prigogina, E. L., Fleischman, E. W.: Marker chromosome 14q+ in two non-Burkitt lymphomas. Humangenetik 30, 113–112 (1975b)
Reeves, B. R.: Cytogenetics of the malignant lymphomas. Studies utilizing a Giemsa-banding technique. Humangenetik 20, 231–250 (1973)
Rowley, D. J.: Do human tumors show a chromosome pattern specific for each etiologic agent? J. Nat. Cancer Inst. 52, 315–320 (1974)
Rowley, J.: Nonrandom chromosomal abnormalities in hematologic disorders of man. Proc. Nat. Acad. Sci. USA 72, 152–156 (1975)
Seabright, M.: A rapid banding technique for human chromosomes. Lancet 1971 II, 971–972
Wurster-Hill, D. H., McIntyre, O. R., Cornwell, G. G., III, Maurer, L. H.: Marker chromosome 14 in multiple myeloma and plasma-cell leukaemia. Lancet 1973 II, 1031
Zankl, H., Zang, K. D.: Cytological and cytogenetical studies of brain tumors. IV. Identification of the missing G chromosome in human meningeomas as No. 22 by fluorescence technique. Humangenetik 14, 167–169 (1972)
Zech, L., Hoglund, U., Nilsson, R., Klein, G.: Characteristic chromosomal abnormalities in biopies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas. Int. J. Cancer 17, 47–56 (1976)
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Fleischman, E.W., Prigogina, E.L. Karyotype peculiarities of malignant lymphomas. Hum Genet 35, 269–279 (1977). https://doi.org/10.1007/BF00446620
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DOI: https://doi.org/10.1007/BF00446620