Summary
A modification of Himsworth’s G.I.T.T. is introduced which consists of the administration of 0.1 units of crystalline insulin intravenously 30 minutes after the intravenous injection of 25 Gms of glucose in 50 per cent solution. This procedure elicited a consistent pattern of response in the 25 normal individuals, the blood sugar falling to fasting level within 45 minutes after the insulin administration. This test in combinaion with the determination of the serum inorganic phosphorus decline after glucose administration promises to provide a clinical means of distinguishing three pathogenetic factors of the diabetic syndrome: hepatic dysfunction, overactivity of insulin antagonists and, by exclusion, primary insulin deficiency. It is suggested that this differentiation may be of practical value for the treatment of the diabetic syndrome.
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Volk, B.W., Lazarus, S.S. A clinical study of the pathogenesis of the diabetic syndrome: Use of a modified glucose insulin tolerance test combined with the change of serum inorganic phosphorus after glucose administration. Amer. Jour. Dig. Dis. 18, 269–274 (1951). https://doi.org/10.1007/BF02896447
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DOI: https://doi.org/10.1007/BF02896447