Abstract
There exists significant individual variation in electroacupuncture (EA) induced analgesia. Rats may be classified as high- and lowresponders according to their response to EA analgesia. The content of cholecystokinin octapeptide like immunoreactivity (CCK-8-ir) in the spinal perfusate of highresponder (HR) and low-responder (LR) rats was measured with radioimmunoassay. The result showed that the CCK-8-ir content in LR rats was significantly lower than that in HR rats. There exists a negative correlation between the EA effect and the CCK-8-ir content during EA stimulation. It is concluded that the spinal release of CCK-8 may be one of the key factors determining the effect of EA analgesia.
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Liu, S., Luo, F., Shen, S. et al. Relationship between the analgesic effect of electroacupuncture and CCK-8 content in spinal perfusate in rats. Chin.Sci.Bull. 44, 240–243 (1999). https://doi.org/10.1007/BF02896283
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DOI: https://doi.org/10.1007/BF02896283