Summary
A dose-dependent incidence of renal sarcomas is observed in young rats soon after neonatal infection with polyoma virus. A significant reduction of DNA-synthesizing cells occurs prior to the onset of tumor-cell proliferation an later even outside the sarcomas. Reduced cell proliferation is manifested by a decreased mitotic index, while grain counts following administration of3H-thymidine do not show any differences. The target cells of polyoma virus, the stromal cells of the kidney, are most severely inhibited. The tubular cells of the kidneys, and the epithelial and stromal cells of the liver are likewise inhibited, whereas the rapidly regenerating duodenal mucosa is spared from the inhibitory effect of polyoma virus. This inhibition of cell proliferation extends for at least 30 days after virus infection. It is suggested that the synthesis of viral antigens is responsible for the inhibition, as the effect was especially pronounced in thymectomized rats.
Zusammenfassung
Während bei einem dosisabhängigen Prozentsatz von Polyoma-infizierten Ratten sehr rasch Fibrosarkome der Niere entstehen, kommt es bereits vor deren Zellproliferation und später außerhalb dieser Tumoren zu einer bemerkenswerten Reduzierung der DNS-synthetisierenden Zellen. Dabei handelt es sich um eine Reduzierung der Zellproliferation, weil auch die Mitoseraten sinken und andererseits die Silberkornzahl gleich bleibt. Die Targetzellen der malignen Transformation, die Stromazellen des Nierenmarkes sind am stärksten von diesem Effekt der Proliferationshemmung betroffen, die tumorpositiven wiederum stärker als die tumorfreien Ratten. Der Hemmungseffekt beschränkt sich nicht auf die Stromazellen, sondern betrifft auch die Epithelien der Niere, die Epithelien der Leber, die Stromazellen der Leber, aber nicht die Epithelien der rasch proliferierenden Duodenalschleimhaut. Es handelt sich nicht um eine transiente kurzfristige Proliferationsänderung, sondern der Effekt dauert mindestens 30 Tage; deshalb wird als Ursache eine Wirkung von Virusantigenen resp. neuen Zeilantigenen vermutet, wofür auch der besonders ausgeprägte Effekt bei gleichzeitig thymektomierten Ratten sprechen könnte.
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Zobl, H., Siegismund, G., Georgii, A. et al. Über eine anhaltende Hemmung der Zellproliferation durch onkogenes Polyomavirus bei Ratten. Virchows Arch B Cell Pathol 16, 281–295 (1974). https://doi.org/10.1007/BF02894082
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DOI: https://doi.org/10.1007/BF02894082