Summary
Recent results of amyloid research suggested we study experimental murine amyloidosis by transferring viable spleen cells to untreated recipients. As donors were used casein treated as well as normal mice. We could show that isogenetic recipients developed amyloidosis, irrespective of its origin, i.e., whether the intraperitoneal injected spleen cells were derived from normal or sensitized animals.
Zusammenfassung
Aus gegebener Veranlassung wurde die Erzeugung von Amyloid in der Maus durch Übertragung von lebenden Mäusemilzzellen auf gesunde Tiere versucht. Als Spender dienten sowohl mit Casein vorbehandelte als auch nicht behandelte Tiere. Es fand sich, daß in den isogenetischen Empfängern Milzamyloid entstand, unabhängig davon, ob die intraperitoneal injizierten Milzzellen aus sensibilisierten oder normalen Tieren stammten.
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Dreher, R., Letterer, E. Experimentelle Amyloidose durch die Übertragung lebender Milzzellen. Virchows Arch. Abt. B Zellpath. 5, 236–241 (1970). https://doi.org/10.1007/BF02893565
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DOI: https://doi.org/10.1007/BF02893565