Skip to main content

Advertisement

SpringerLink
Log in

Augmentation of urinary amylase output by excessive diuresis in rats and abolition of this phenomenon by pancreatectomy

  • Original Article
  • Published:
Gastroenterologia Japonica Aims and scope Submit manuscript

Summary

Effects of diuresis on urinary amylase output were observed in control and pancreatectomized rats on the administration of tap water, glucose and amino acid solution.

  1. (1)

    Urine volume and urinary amylase output were increased as the concentration of glucose solution was increased. Amylase output in the urine revealed a positive correlation with the urine volume.

  2. (2)

    Augmentation of urinary amylase output was also observed in diuretic rats produced by the administration of amino acid solution.

  3. (3)

    Augmentation of urinary amylase output was not found in pancreatectomized rats, although the urine volume was more pronouncedly increased compared to control rats.

  4. (4)

    The urinary amylsae output revealed a positive correlation with the ratio of amylase clearance to creatinine clearance by the kidney in control rats, while the output remained unchanged over relatively wide range of the ratio in pancreatectomized rats. Above evidences indicated that urinary amylase output was significantly augmented by excessive diuresis and that the increased urinary amylase output originated from the pancreas

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. McGeachin, R.L., and Hargan, L.A. ; Amylase clearance and excretion during water diuresis. Proc. Soc. Exp. Biol. & Med., 95: 341, 1957

    CAS  Google Scholar 

  2. Duane, W.C., Frerichs, R., and Levitt, M.D.; Distribution, turnover, and mechanism of renal function of amylase in the baboon. J. Clin. Invest., 50:156, 1971

    Article  PubMed  CAS  Google Scholar 

  3. Nothman, M.M., and Callow, A.D.; Investigations on the origin of amylase in serum and urine. Gastroenterology, 60:80, 1971

    Google Scholar 

  4. Treadwell, C.R., and Roe, J.H., Jr.: Technic for complete pancreatectomy in the rat. Proc. Soc. Exp. Biol. & Med., 86:878, 1954

    CAS  Google Scholar 

  5. Blainey, J.D., and Northman, B.E.; Amylase excretion by the human kidney. Clin. Sci., 32:377, 1967

    PubMed  CAS  Google Scholar 

  6. Mulhausen, R., Brown, D.C., and Onstad, G. ; Renal clearance of amylase during pancreatitis, Metabolism, 18:669, 1969

    Article  PubMed  CAS  Google Scholar 

  7. Levitt, M.D., Rapoport, M., and Cooperband, S.R.; The renal clearance of amylase in renal insufficiency, acute pancreatitis, and macroamylasemia, Ann. Intern. Med., 71: 919, 1969

    PubMed  CAS  Google Scholar 

  8. Noda, A.; Renal handling of amylase: evidence for reabsorption by stopflow analysis, Metaboilsm, 21:351, 1972

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Third Department of Internal Medicine, Tokyo Medical and Dental University, No. 5-45, 1-Chome, Yushima, Bunkyoku, Tokyo, Japan

    Hidenori Maezawa M. D., Sayo Ogawa M. D. & Yukio Ito M. D.

Authors
  1. Hidenori Maezawa M. D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sayo Ogawa M. D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yukio Ito M. D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Maezawa, H., Ogawa, S. & Ito, Y. Augmentation of urinary amylase output by excessive diuresis in rats and abolition of this phenomenon by pancreatectomy. Gastroenterol Jpn 9, 1–8 (1974). https://doi.org/10.1007/BF02892448

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02892448

Key words

Search

Navigation