Summary
Plasma and pituitary extracts from hepatectomized mice as well as pure growth hormone, stimulate DNA synthesis in hepatocyte population of adult intact mouse liver. This effect is not observed with plasma and pituitary extracts from intact or sham operated mice. The corresponding effects on the litoral cell population of the liver follow the same pattern, but the results are not so clearcut as in the hepatocyte population. The possibility that growth hormone, released by STH cells of the pituitary, is one of the factors responsible for the stimulating effect of plasma during liver regeneration, is discussed on the basis of the present results and of those already reported in the literature.
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Supported by grants from the Consejo Nacional de Investigaciones Científicas y Técnicas de la Republica Argentina, the Comisión de Investigación de la Universidad Nacional de La Plata and the Comisión de Investigación Cientifica de la Provincia de Buenos Aires. Thanks are due to the members of the technical Staff of the Institute for their technical assistance.
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Badran, A.F., Llanos, J.M.E. & Surur, J.M. The pars distalis of the pituitary as a source of liver growth stimulating factors during liver regeneration. Virchows Arch. Abt. B Zellpath. 13, 79–85 (1973). https://doi.org/10.1007/BF02889299
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DOI: https://doi.org/10.1007/BF02889299