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Studies on metal phthalocyanine as a dual functional mimic enzyme

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Summary

Four phthalocyanines (iron tetracarboxylphthalocyanine, copper tetracarboxylphthalocyanine, manganese tetracarboxylphthalocyanine, cobalt tetracarboxylphthalocyanine) were used as dual functional mimic enzymes of Superoxide dismutase (SOD) and catalase (CAT). The first function, eliminating O2 -, was proved by using riboflavine-methionine photoreduction method in the concentration range of 10-5 to 10-6 mol/L. The second function, clearing out H2O2, was demonstrated by means of spectrophotometry with the decomposing percentage being increased with the increase of the concentration of the imitating compounds. Measurements of metal phthalocyanines, SOD and CAT by the liver homogenate technique of mice showed that they had obvious action of decreasing the lipid peroxidation.

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Authors and Affiliations

  1. Department of Chemistry, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan

    Feng Qing (Associate Professor), Liu Li & He Yongyan

  2. Department of Chemistry, Huazhong University of Science and Technology, 430070, Wuhan

    Wang Hailong, Wu Mingyuan & Mei Fuming

Authors
  1. Feng Qing
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  2. Liu Li
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  3. He Yongyan
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  4. Wang Hailong
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  5. Wu Mingyuan
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  6. Mei Fuming
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Additional information

This project was supported by a grant from National Natural Science Foundation of China (No. 39370784).

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Qing, F., Li, L., Yongyan, H. et al. Studies on metal phthalocyanine as a dual functional mimic enzyme. Current Medical Science 21, 13–16 (2001). https://doi.org/10.1007/BF02888025

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  • DOI: https://doi.org/10.1007/BF02888025

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