Summary
The present experiment employed the immunohistochemical technique and morphological observation to investigate the expression and distribution of C3, C4, IgG, IgE and 5-HT in portal hypertensive pigs with pathological change of gastric mucosa and gastric parietal vessels. The wall of gastric mucosal microvessels in portal hypertensive pigs had a positive or strong positive reaction of C3, C4, IgG, IgE and 5-HT with obvious injury of gastric mucosa normal pigs imparted negative or feeble positive reaction, suggesting that during portal hypertension, the gastric mucosal micro-vessels has deposit of immunocomplexes resulting in the injury of the micro-vessels. It might be a factor involved in the pathogenesis of the gastric mucosal lesion during portal hypertension with cirrhosis.
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This project was supported by the National Natural Science Foundation (No. 39470685).
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Mba, C.M., Zhen, Y. Role of injury of gastric parietal vessels by immunocomplexes in the mechanism of gastric mucosal lesion in portal hypertension with cirrhosis. Current Medical Science 17, 44–48 (1997). https://doi.org/10.1007/BF02888002
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DOI: https://doi.org/10.1007/BF02888002