Summary
The changes in the activities of constitutive nitric oxide (NO) synthase (cNOS) and inducible NOS (iNOS) were investigated in arterial tissues of CC14-induced cirrhotic adult SD rats. The aortic tissue homogenate were prepared in normal and cirrhotic rats. NOS activity was measured by conversion of3H-arginine to3H-citrulline. The activities of cNOS and iNOS were calculated in terms of presence or absence of Ca2+. The results showed that activities of total NOS, cNOS and iNOS in arterial tissues were all increased significantly in cirrhotic rats as compared with those in normal controls. There was a significant positive correlation between the activities of total NOS and cGMP content in cirrhotic arterial tissues.
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Pili, Z., Kuohuan, L., Jusheng, L. et al. Nitric oxide synthase activity in arterial tissues of cirrhotic rats. Current Medical Science 17, 25–27 (1997). https://doi.org/10.1007/BF02887997
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DOI: https://doi.org/10.1007/BF02887997