Summary
A panel of monoclonal antibodies (McAb) from the Wu series was used to characterize lymphocyte subsets of peripheral blood (PB) from 9 patients with multiple myeloma (MM) by means of indirect immunofluorescence assay. In 7 of these patients bone marrow (BM) cells were also studied. Abnormal distribution of T lymphocyte subsets was observed in these patients, and the alterations were quite similar in both PB and BM. A significant increase in the proportion of WUT +8 cells (P<0.00l) and a reduced WuT4/WuT8 ratio (P<0.001) were found in patient group. In both PB and BM of patients, WuT +10 cell counts were significantly higher than normal (P<0.00l). There was a good correlation between BM WuT +10 cells and BM myeloma cells (r= 0.76, P<0.05), whereas no correlation was found between PB WuT +10 cells and BM myeloma cells. The significance of abnormal T-cell subset distribution and elevated WuT +10 cells in MM is discussed.
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Lan-qing, H., Jin-zhi, T., Guan-xin, S. et al. Peripheral blood and bone marrow lymphocyte subsets in patients with multiple myeloma. Journal of Tongji Medical University 10, 73–76 (1990). https://doi.org/10.1007/BF02887864
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DOI: https://doi.org/10.1007/BF02887864