Summary
The toxicokinetics of methyl-ISP was studied in rats. The logarithm of the pesticide concentration in blood versus time curve following intravenous injection was fitted to two-compartment open model. The toxicokinetic parameters are as follows: distribution half life 2 min, elimination half life 3 h, apparent volume of distribution 335.03 ml/100g, total tody clearance 1.28 ml/100g/min. After intravenous injection, the pesticide was distributed mainly in the liver and the lungs, where at subcellular level it was chiefly concentrated in nuclei and mitochondria. 66.43% of the total amount of the pesticide administered was excreted in feces and urine, especially in feces.
It was easily absorbed through the gastrointestinal tract.
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Nian, S., Zhj-wei, L., Hui-qiong, W. et al. The toxicokinetics of methyl-ISP in rats. Journal of Tongji Medical University 8, 78–82 (1988). https://doi.org/10.1007/BF02887798
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DOI: https://doi.org/10.1007/BF02887798