Summary
To explore the inhibitory effects of anti-CD4 human/murine chimeric antibodies on lymphocyte proliferation, CD4+ T cell apoptosis induced by anti-CD4 antibodies was examined. Annexin-V-FITC and PI double stain method was employed to qualitatively and quantitatively determined CD4+ T cell apoptosis induced by anti-CD4 antibodies. Our results showed that anti-CD4 chimeric antibodies could specifically induce CD4+ T cell apoptosis. The ability of anti-CD4 chimeric antibodies to induce CD4+ T cell apoptosis was related with the presence of monocytes. It is concluded that the further cross-linking of anti-CD4 antibodies is important for inducing CD4+ T cell apoptosis.
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This project was supported by grant from the National Sciences Foundation of China (No. 39370628).
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Zhihong, Z., Yue, Z., Huifen, Z. et al. Cd4+ T cell apoptosis induced by anti-CD4 antibodies. Current Medical Science 20, 100–102 (2000). https://doi.org/10.1007/BF02887041
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DOI: https://doi.org/10.1007/BF02887041