Summary
To investigate the difference of biochemical characteristics on gsp-positive and gsp-negative growth hormone (GH)-secreting pituitary tumors, 18 GH-secreting pituitary tumors were examined for their clinical characteristics and gsp oncogenes. All patients received the pituitary function combinative stimulating test. It was found that there were no difference in the sex, age, tumor size, course of disease and plasma basal GH levels with gsppositive and gsp-negative patients. The plasma levels of PRL were increased in most patients (11/18), and the plasma levels of TSH in gsp-positive patients were higher than those in gsp-negative patients (P < 0.05). There was no significant difference in the responses to pituitary combinative stimulating test in gsp-positive and gsp-negative patients. It was concluded that there was little difference in the clinical biochemical characteristics of gsp-positive with gsp-negative GH-secreting pituitary tumors.
Similar content being viewed by others
References
gsp 2000, 17(l):18
Lei T, Adams E F, Buchfelder Met al. Relationship between protein kinase C and adenylyl cyclase activity in the regulation of growth hormone secretion by human pituitary somatotrophinomas. Neurosurgery, 1996, 39:569
Landis C A, Masters S B, Spada Aet al. GTPase inhibiting mutations activate the α-chain of Gs and stimulate adenylyl cyclase in human pituitarytumors. Nature, 1980, 340:692
Adams E F, Mashiter K. Secretion of growth hormone by normal and tumous human pituitary somatotrophs in cell culture. Endocrinology’ 85, Excerpta Medica, 1986. 75
Adams E F, Lei T, Buchfelder Met al. Biochemical characteristics of human pituitary somatotrophinomas with and without gsp mutation: in vitro cell culture studies. J Clin Endocrinol Metab, 1995, 80:2077
Bresson-Bepoldin L, Odessa M F, Dufy-Barbe L. GHRP-6 stimulates calcium increase and growth hormone release in human somatotrophs in vitro. Endocrine J, 1994, 2: 793.
Author information
Authors and Affiliations
Additional information
This project was supported by a grant from the National Natural Sciences Foundation of China (No. 39670736).
Rights and permissions
About this article
Cite this article
Xiangjun, B., Ting, L. & Kui, L. Clinical and biochemical characteristics of growth hormone-secreting pituitary tumors. Current Medical Science 20, 212–213 (2000). https://doi.org/10.1007/BF02886993
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02886993