Abstract
A 26-year-old male, who had prior trans-sphenoidal pituitary surgery, presented with gigantism. He was treated with adjunctive; Linac-based SRS for post-surgical residual, GH-secreting pituitary adenoma. The target volume of 0.5 cc received a marginal dose of 16.0 Gy normalized to 80% isodose line. The maximum dose to optic chiasm was 9.4 Gy. Serial post-SRS follow-up MRIs showed mild decrease in tumor size and contrast enhancement. At last follow-up (36 months post-SRS), the patient’s gigantic features remained unchanged. However, hormonal assays (GH and IGF-1 serum levels) were normalized. Continued clinical, endocrinological, and radiological follow-ups were advised.
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Further Reading
Abdelaziz OS. Stereotactic radiosurgery for benign brain tumors: treatment rationale and outcomes. J Radiosurg. 2000;3(1):29–42. https://doi.org/10.1023/A:1009573119807.
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Mathieu D, Kotecha R, Sahgal A, et al. Stereotactic radiosurgery for secretory pituitary adenomas: systematic review and International Stereotactic Radiosurgery Society practice recommendations. J Neurosurg. 2022;136(3):801–12.
Minniti G, Osti MF, Niyazi M. Target delineation and optimal radiosurgical dose for pituitary tumors. Radiat Oncol. 2016;11:135.
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Abdelaziz, O.S., De Salles, A.A.F. (2023). Growth Hormone (GH)-Secreting Pituitary Adenoma (Gigantism). In: NeuroRadiosurgery: Case Review Atlas. Springer, Cham. https://doi.org/10.1007/978-3-031-16199-5_40
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DOI: https://doi.org/10.1007/978-3-031-16199-5_40
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