Skip to main content
SpringerLink
Log in

Effects of amrinone on cardiac contraction and relaxation in isolated, perfused rat heart

  • Published:
Journal of Tongji Medical University Aims and scope Submit manuscript

Summary

The effects of amrinone on cardiac contraction and relaxation were assessed in isolated, perfused rat hearts. It was found that the left ventricular developed pressure (LVDP). dp/dtmax and -da/dtmax did not significaptly increase, and the time constant (τ) did not markedly shorten with perfusion of low concentration (1 nmol/L. 100 nmol/L) of amrinone. The perfusion with higher concentration (1000 nmol/L) of amrinone. reduced LVDP (P<0.01), dp/dtmax (P<0.01), -dp/dtmax, (P<0.01), and prolonged τ (P< 0. 05) significantly. It was assumed that amrinone has no direct positive inotropic effect, and can not improve cardiac relaxation. On the contrary, the cardiac contraction and relaxation will be inhibited at higher concentration of amrinone.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Buser P T, Auffermann W, Wu S Tet al. Dobutamine potentiates amrinone’s beneficial effects in moderate but not in advanced heart failure. Circ Res, 1990, 66: 747

    PubMed  CAS  Google Scholar 

  2. Wilmshurst P T, Thompson D S, Juue S Met al. Effects of intracoronary and intravenous amrinone infusions in patients with cardiac failure and patients with near normal cardiac function. Br Heart J, 1985; 53: 493

    Article  PubMed  CAS  Google Scholar 

  3. Wilmshurst P T, Thompson D S, Juue S Met al. Comparison of the effects of amrinone and sodium nitroprusside on haemodynamics, contractility, and myocardial metabolism in patients with cardiac failure due to coronaryartery disease and dilated cardiomyopathy. Br Heart J, 1984; 52: 38

    Article  PubMed  CAS  Google Scholar 

  4. Onuaguluchi G, Tanz R D. Cardiac effects of amrinone on rabbit papillary muscle and guineapig langendorff heart preparations. J Cardiovasc Pharmacol, 1981; 13: 1342

    Article  Google Scholar 

  5. Wilmshurst P T, Thompson D S, Jenkins B Set al. Haemodynamic effects of intravenous amrinone in patients with impaired left ventricular function. Br Heart J, 1983; 49: 77

    Article  PubMed  CAS  Google Scholar 

  6. Firth B G, Ratner A V, Grassman E Det al. Assessment of the inotropic and vasodilator effects of amrinone versus isoproterenol. Am J Cardiol, 1984; 54: 1331

    Article  PubMed  CAS  Google Scholar 

  7. Azari J, Huxtable R J. Differential effects of amrinone on contractility and taurine influx in rat and guinea pig hearts. Eur J Pharmacol, 1980; 67: 347

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicien, Tongji Hospital, Tongji Medical University, Wuhan

    Ma Ye-xin & Zhao Hua-yue

Authors
  1. Ma Ye-xin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zhao Hua-yue
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ye-xin, M., Hua-yue, Z. Effects of amrinone on cardiac contraction and relaxation in isolated, perfused rat heart. Journal of Tongji Medical University 14, 165–168 (1994). https://doi.org/10.1007/BF02886799

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02886799

Key words

Search

Navigation