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Critical evaluation of γ-glutamyl transpeptidase levels in rheumatoid arthritis and laboratory indices of disease activity

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Ricerca in clinica e in laboratorio

Summary

Fifty patients with rheumatoid arthritis (RA) were studied to find a possible correlation between some humoral parameters, considered as indexes of the active inflammation, and serum γ-glutamyl transpeptidase (GGTP); 31 patients with osteoarthrosis were examined as controls. The low coefficient of correlation, obtained in subjects with RA, between GGTP and CRP, α1-acid glycoprotein, fibrinogen and ESR (p<0.05) seems to indicate that measurement of this enzyme is of little practical value as an index of the activity of RA. Furthermore, the resulting correlations between serum GGTP and other liver function tests in relation to anti-inflammatory and sedative therapy in patients with RA are considered.

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Authors and Affiliations

  1. Cattedra di Reumatologia, Università degli Studi di Firenze, Via Camporeggi 2, 50129, Firenze, Italia

    Gianfranco Bianucci, Stefania Pinto, Susanna Maddali Bongi & Silvana Saullo

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  1. Gianfranco Bianucci
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  2. Stefania Pinto
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  3. Susanna Maddali Bongi
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  4. Silvana Saullo
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Bianucci, G., Pinto, S., Bongi, S.M. et al. Critical evaluation of γ-glutamyl transpeptidase levels in rheumatoid arthritis and laboratory indices of disease activity. La Ricerca Clin. Lab. 11, 159–168 (1981). https://doi.org/10.1007/BF02886716

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