Summary
The hematological and cytogenetical studies of a case of atypical myeloproliferative disorder are reported. The patient displayed moderate leukocytosis, anemia and thrombocytopenia. Reduced or absent growth of CFU-C was observed in the bone marrow and peripheral blood. The cytogenetical analysis revealed a trisomy 21 limited to the neoplastic clone. The overall results are discussed and compared with the rare cases of acquired trisomy 21 reported in the literature.
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This work was supported byConsiglio Nazionale delle Ricerche (CNR), Roma, Italy, ‘Centro Studio Immunogenetica ed Istocompatibilità’ andProgetto Finalizzato Controllo della Crescita Neoplastica
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Ponzio, G., Aglietta, M., Piacibello, W. et al. Atypical myeloproliferative disorder associated with a 21 trisomic clone. La Ricerca Clin. Lab. 11, 111–115 (1981). https://doi.org/10.1007/BF02886709
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DOI: https://doi.org/10.1007/BF02886709