Abstract
The accumulation of the large amount of biological data concerning with gene and protein research has proposed that it is necessary to abstract the biological significance from these data. Then the bioinformatics, equipped with the most advanced computational techniques and supported by the latest biological research, has emerged for this purpose. Some recent information on the developing bioinformatics, associated with the uniform resource location addresses of those available resource sites that support hyper-text or general file transfer protocols on the Internet, from points like bioinformation databases of gene sequence or protein structure, general biocomputing softwares for genome analysis or protein structure analysis, online biocomputing servers dedicated for genomic database search or protein steric structure recognition and prediction, artificial life, etc. is reviewed. There are also other various approaches like Usenet, Newsgroup that focus on their specific topics introduced. Finally, the hottest problems and most gifted respects of the bioinformatics are discussed, whereas the bioinformatics has been regarded as an international cooperation in sciences, as well as a new challenge for life scientists in China.
Similar content being viewed by others
References
Rodrigursz-Tome, P., The Bincatalog,Bioinformatics, 1998, 14(5): 469.
Cooper, D. N., Ball, E.V., Krawczak, M., Thehuman gene mutation database,Nucleic Acids Res., 1998, 26(1): 285.
Sugawara. H., Miyazaki, S., Towards the Asia-Pacific Bioinfonnatics Network,Poc. Symp. Biocomput., 1998, (4): 759.
Attwood, T. K., Beck, M. E., Uower, D. R.et al., The PRINTS protein fingerprint database in its fifth year,Nucleic Acids Res., 1998, 26(1): 304.
Bono, H., Ogata, H., Goto, S.et al., Reconstruction of amino acid biosynthrsis pathways from the complete genome sequencemGenome Res., 1998, 8(3): 203.
Clemet, E., Coclani, J. J., LASSAP, a LArge Scale Sequence compArison Package,CABIOS, 1997. 13(2): 137.
Womiak, A., Using video oriented instructions to speed-up sequence comparison,CABIOS, 1997, 13(2): 145.
Proutski, V., Holmes, F., SWAN: sliding windows analysis of nucleotide srquenre variability,Bioinformatics, 1998, 14 (5): 467.
Trelles, O., Andrade, M. A., Valencia, A.et al., Computational space reduction and parallelization of a new clustering epproach for large groups of sequences,Bioinformatics, 1998, 14(5): 439.
Krause, A., Vingron, M., A set-theoretic approach to database searching and clustering,Bioinformatics, 1998, 14(5): 430.
Lijnzaad, P., Helgewn, C., Rodriguez-Tome, P., The Radiation Hybrid Database,Nucleic Acids Res., 1998, 26(1): 102.
Stoesser, G., Moseley, M. A., Sleep, J.et al., The EMBL nucleutide sequence database,Nucleic Acids Res., 1998, 26 (1): 8.
Van Ommen, G. J., The human genome project and the mle of genetics in health care,Clin. Chem. Lab. Med., 1998, 36 (8): 515.
Rebhan, M., Chalifa-Caspi, V., Prilusky, J.et al., GeneCards: a novel functional genomics cumpendium with automated data mining and query reformulation support,Bioinformatics, 1998, 14(8): 656.
Sorace, J. M., Canfield, K., Collaborative bioinformatics: data warehouses for targeted experimental results,J. Interferon Cytokine Res., 1998, 18(9): 799.
Borsani, G., Ballabio, A., Banfi, S., A practical guide to orient yourself in the labyrinth of genome databases,Hum. Mol. Genet., 1998, 7(10): 1641.
Goodman, N., Rozen, S., Stein, L. D.et al., The LabBase system for data management in large scale biology research laboratories,Bioinformatics, 1998, 14(7): 562.
Baxevanis, A. D., The Internet and the biologist,Methods Biochem Anal., 1998, 39: 1.
Gaasterland, T., Structural genomics: bioinformatirs in the driver’s seat,Nat Biotechnol., 1998, 16(7): 625.
Wu, C. H., Shivakumar, S., Shivakumar, C. V.et al., GeneFIND web server for protein family identification and information retrieval,Bioinformatics, 1998, 14(2): 223.
Kastin, S., Wexler, J., Bioinformatics: searching the Net,Semin. Nucl. Med., 1998, 28(2): 177.
Stein, L. D., Cartinhour, S., Thieny-Mieg, D.et al., JADE: an approach for interconnecting bioinformatics databases,Gene, 1998, 209(1-2): 39.
Baker, P. G., Brass, A., Recent developments in biological sequence databases,Curr. Opin. Biotechnol., 1998, 9(1): 54.
Author information
Authors and Affiliations
About this article
Cite this article
Ouyang, S., He, F. Bioinformatics, robust realm based upon multidisciplinary knowledge of biological data and computational techniques. Chin. Sci. Bull. 44, 1825–1837 (1999). https://doi.org/10.1007/BF02886336
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02886336