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Synthesis and relaxivity of polycarboxylic hydrazone rare earth complexes

Relaxivity of α-oxo-pentanedioic acid benzoyl hydrazone Gd-complexes

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Chinese Science Bulletin

Abstract

Synthesis of ligand, α-oxo-pentanedioic acid benzoyl hydrazone (H2LPB), and its six rare earth (La, Pr, Nd, Sm, Gd and Er) complexes are reported. The composition and the properties of the complexes were characterized by element analysis, thermal analysis, UV, IR and1H NMR spectra. Besides, relaxivity (R 1) of Gd-complex has been determined by INVREC.Au program, using inversion recovery pulse sequences, R1=8.05 mmol · L−1 · s−1. The acute toxicity of Gd-complex in animal has also been tested, and the median lethal dose (LD50) is equal to (468.2±30) mg/kg.

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Authors and Affiliations

  1. Chemistry and Engineering College, Lanzhou University, 730000, Lanzhou, China

    Zhengyin Yang & Rudong Yang

  2. Department of Physics, Lanzhou University, 730000, Lanzhou, China

    Fashen Li

  3. National Laboratory of Applied Organic Chemistry, Lanzhou University, 730000, Lanzhou, China

    Li Yang

Authors
  1. Zhengyin Yang
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  2. Fashen Li
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  3. Li Yang
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  4. Rudong Yang
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Correspondence to Zhengyin Yang.

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Yang, Z., Li, F., Yang, L. et al. Synthesis and relaxivity of polycarboxylic hydrazone rare earth complexes. Chin.Sci.Bull. 45, 1844–1850 (2000). https://doi.org/10.1007/BF02886291

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  • DOI: https://doi.org/10.1007/BF02886291

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