Skip to main content
Log in

Amperometric determination of ascorbic acid at a thin layer flow cell

  • Original Articles
  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript

Abstract

A thin layer flow cell with cell volume of 8 μl was constructed. Diffusion currents of ascorbic acid was directly proportional to the 1/3 power of volume flow rates. A linear dynamic range was obtained at the concentration range between 10−7 M and 10−4 M of ascorbic acid with a detection limit of 10−8 M. Ascorbic acid in the multivitamin product was amperometrically determined at TLFC after simply dissolving mg range ground product in 100ml of pH 7.0 phosphate buffer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Literature Cited

  1. Goodman, L.S. and Gilman, A.:The Pharmacological Basis of Therapeutic 5th ed. Macmillan, N.Y. pp 1564–1568 (1975).

    Google Scholar 

  2. Korean pharmacopeia 3rd ed., p. 279 (1976).

  3. Rukmini, N., Kavitha, V.S.N.P., and Vijaya, K.D.: Determination of Ascorbic Acid with Ferricyanide,Talanta 28, 332 (1981).

    Article  CAS  Google Scholar 

  4. Elnenaey, E.S. and Soliman, R.: A Sensitive Colorimetric Method for the Estimation of Ascorbic Acid,Talanta 26, 1164 (1979).

    Article  CAS  Google Scholar 

  5. Mason, W.D., Gardner, T.D. and Stewart, J.T.: Determination of Ascorbic Acid in Pharmaceutical Dosage Forms Based on Oxidation at the Tubular Carbon Electrode,J. Pharm. Sci.,61, 1301 (1972).

    Article  PubMed  CAS  Google Scholar 

  6. Blaedel, W.J. and Meloche, V.W.:Elementary Quantitative Analysis, Theory and Practice, 2nd ed., Harper & Row, N.Y., pp 895–897 (1963).

    Google Scholar 

  7. Elbicki, J.M., Morgan, D.M. and Weber, S.G.: Theoretical and Practical Limitations on the Optimization of Amperometric Detectors,Anal. Chem.,56, 978 (1984).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hahn, Y. Amperometric determination of ascorbic acid at a thin layer flow cell. Arch. Pharm. Res. 11, 56–60 (1988). https://doi.org/10.1007/BF02884769

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02884769

Keywords

Navigation