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CytochromeC methylation: Current knowledge of its biological significance

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Abstract

The yeast cytochromec gene has been recloned, and the resulting cytochromec mRNA has been translated in rabbit reticulocyte lysate translation system. The newly synthesized apocytochromec could be methylated by exogenously added cytochromec-lysine N-methyltransferase. Enzymatic methylation ofin vitro synthesized apocytochromec was found to facilitate specifically its import into mitochondria of yeast, but not of rat liver.

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Literature Cited

  1. Paik, W.K. and Kim, S.:Science,172, 114 (1971).

    Article  Google Scholar 

  2. Paik, W.K. and Kim, S.:Protein Methylation. Biochemistry: A Series of Monographs, Vol. 1, John Wiley & Sons, New York (1980).

    Google Scholar 

  3. Paik, W.K. and Kim, S.: In:The Enzymology of Post-Translational Modifications of Proteins (Eds. R.B. Freedman and H.C. Hawkins), Academic Press, New York, Vol. 2 (1985), pp. 187–228.

    Google Scholar 

  4. Paik, W.K., Lee, H.W. and Kim, S.: In:Protein/ Peptide Sequence Analysis: Current Methodology (Eds. A.S. Bhown), CRC Press (1987),in press.

  5. Paik, W.K and Kim, S.:J. Biol. Chem. 243, 2108 (1968).

    PubMed  CAS  Google Scholar 

  6. Kim, S. and Paik, W.K.:J. Biol. Chem. 245, 1806 (1970).

    PubMed  CAS  Google Scholar 

  7. Paik, W.K. and Kim, S.:J. Biol. Chem. 245, 6010 (1970).

    PubMed  CAS  Google Scholar 

  8. Wallwork, J.C., Quick D.P. and Duerre, J.A.:J. Biol. Chem. 252, 5977 (1977).

    PubMed  CAS  Google Scholar 

  9. Durban, E., Nochumson, S., Kim, S., Paik, W.K. and Chan, S.-K.:J. Biol. Chem. 253, 1427 (1978)

    PubMed  CAS  Google Scholar 

  10. Sitaramayya, S., Wright, L.S. and Siegel, F.L.:J. Biol. Chem. 255, 8894 (1980).

    PubMed  CAS  Google Scholar 

  11. Lee, H.W., Kim, S. and Paik, W.K.:Biochemistry,16, 78 (1977).

    Article  PubMed  CAS  Google Scholar 

  12. Baldwin, G.S. and Carnegie, P.R.:Science,171, 579 (1971).

    Article  PubMed  CAS  Google Scholar 

  13. LaBadie, J.H., Dunn, W.A. and Aronson, N.N.:Biochem. J. 160, 85 (1976).

    PubMed  CAS  Google Scholar 

  14. Kleene, S.J., Toews, M.L. and Adler, J.:J. Biol. Chem. 252, 3214 (1977).

    PubMed  CAS  Google Scholar 

  15. Van Der Werf, P. and Koshland jr., D.E.:J. Biol. Chem. 252, 2793 (1977).

    Google Scholar 

  16. Olsson, M. and Lindahl, T.:J. Biol. Chem. 255, 10569 (1981).

    Google Scholar 

  17. Paik, W.K., Polastro, E. and Kim, S.: InCurrent Topics in Cellular Regulation, (Eds. B.L. Horecker and E.R. Stedtman), Academic Press, New York, Vol. 16 (1980), pp. 87–111.

    Google Scholar 

  18. Paik, W.K., Farooqui, J.Z and Kim, S.: InAdvances in Enzyme Regulation (Eds. G. Weber), Pergamon Press, New York, Vol. 19 (1981), pp. 471–486.

    Google Scholar 

  19. Paik, W.K. and Kim, S.: InBiological Methylation and Drug Design (Eds. R.T. Borchardt, C.R. Creveling and P.M. Ueland), Humana Press, Clifton (1986), pp. 15–23.

    Google Scholar 

  20. Dickerson, R.E., Takano, T., Eisenberg, D., Kallai, O. B., Samson, L., Cooper, A. and Margoliash, E.:J. Biol. Chem. 246, 1511 (1971).

    PubMed  CAS  Google Scholar 

  21. Takano, T., Kallai, O.B., Swanson, R. and Dickerson, R.E.:J. Biol. Chem. 248, 5234 (1973).

    PubMed  CAS  Google Scholar 

  22. Tanaka, N., Yamane, T., Tsukihara, T., Ashida, T. and Kakudo, M.:J. Biochem. (Tokyo),77, 147 (1975).

    PubMed  CAS  Google Scholar 

  23. Dayhoff, M.O.:Atlas of Protein Sequence and Structure. Vol. 5 (1972), D-13 to D-24. National Biomedical Research Foundation.

    Google Scholar 

  24. Dickerson, R.E. and Timkovich, R.: InEnzymes (Eds. P. Boyer), 3rd Ed., Vol.11. Academic Press, New York (1975), pp. 397.

    Google Scholar 

  25. Speck, S.H., Koppenol, W.H., Osheroff, N., Dethmers, J.K., Kang, C.H., Margoliash, E. and Ferguson-Miller, S.: InMembrane Bioenergetics (Eds. C.P. Lee, G. Schatz and L. Ernster), Addison-Wesley (1979), pp.31–43.

  26. Ferguson-Miller, S., Brautigan, D.L. and Margoliash, E.: InThe Porphyrins (Eds. D. Dorphin), Academic Press (1979), pp.149–241.

  27. DeLange, R.J., Glazer, A.N. and Smith, E.L.:J. Biol. Chem. 244, 1385 (1969).

    PubMed  CAS  Google Scholar 

  28. DeLange, R.J., Glazer, A.N. and Smith, E.L.:J. Biol. Chem. 245, 3325 (1970).

    PubMed  CAS  Google Scholar 

  29. DiMaria, P., Polastro, E., DeLange, R.J., Kim, S. and Paik, W.K.:J. Biol. Chem. 254, 4645 (1979).

    PubMed  CAS  Google Scholar 

  30. DiMaria, P., Kim, S. and Paik, W.K:Biochemistry,21, 1036 (1982).

    Article  PubMed  CAS  Google Scholar 

  31. Farooqui, J., Kim, S. and Paik, W.K.:J. Biol. Chem. 255, 4468 (1980).

    PubMed  CAS  Google Scholar 

  32. Reporter, M.:Arch. Biochem. Biophys. 158, 577 (1973).

    Article  PubMed  CAS  Google Scholar 

  33. Chen, J.-K. and Liss, M.:Biochem. Biophys. Res. Communs. 84, 261 (1978).

    Article  CAS  Google Scholar 

  34. Matsuura, S., Arpin, M. Hannum, C., Margoliash, E., Sabatini, D.D and and Morimoto T.:Proc. Natl. Acad. Sci. USA,78, 4368 (1981).

    Article  PubMed  CAS  Google Scholar 

  35. Park, K.S., Frost, B.F., Tuck, M., Ho, L.L., Kim, S. and Paik, W.K.:J. Biol. Chem. in press (1987).

  36. Van Noort, J.M., Kraal, B., Sinjorgo, K.M.C., Persoon, N.L.M. and Johanns, D.:Eur. J. Biochem. 160, 557 (1986).

    Article  PubMed  Google Scholar 

  37. Polastro, E., Schneck, A.G., Leonis, J., Kim, S. and Paik, W.K.:Intern. J. Biochem. 9, 795 (1978).

    Article  CAS  Google Scholar 

  38. Hay, R., Boehni, P. and Gasser, S.:Biochim. Biophys. Acta,779, 65 (1984).

    PubMed  CAS  Google Scholar 

  39. Henning, B., Koehler, H. and Neupert W.:Proc. Natl. Acad. Sci. USA,80, 4963 (1983).

    Article  Google Scholar 

  40. Enosawa, S. and Ohashi, A.:Biochem. Biophys. Res. Communs. 141, 1145 (1986).

    Article  CAS  Google Scholar 

  41. Henning, B. and Neupert, W.:Proc. Natl. Acad. Sci. USA,121, 203 (1981).

    Google Scholar 

  42. Scott, W.A. and Mitchell, H.K.:Biochemistry,8, 4282 (1969).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Fels Research Institute, Temple University School of Medicine, 19140, Philadelphia, PA, USA

    Kwang Sook Park, Blaise F. Frost, Sangduk Kim & Woon Ki Paik

  2. School of Pharmacy, Sung Kyun Kwan University, 440-746, Suwon, Korea

    Hyang Woo Lee

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  1. Kwang Sook Park
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  2. Blaise F. Frost
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  3. Hyang Woo Lee
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  4. Sangduk Kim
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  5. Woon Ki Paik
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Park, K.S., Frost, B.F., Lee, H.W. et al. CytochromeC methylation: Current knowledge of its biological significance. Arch. Pharm. Res. 11, 7–13 (1988). https://doi.org/10.1007/BF02884763

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