Abstract
Physical and chemical agents were employed in our laboratories to induce mutation in a variety of microorganisms used for production of antibioties or enzymes. Improved production strains ofPenicillium chrysogenum (penicillin-producer),Streptomyces griseus (streptomycin-producer),Streptomyces nodosus. (amphotericin B-producer),Streptomyces noursei (nystatin-producer),Streptomyces umbrinus (diumycin-producer),Streptomyces prasinus (prasinomycin-producer),Streptomyces roseochromogenes (steroid-16α-hydroxylase-producer), andArthrobacter simplex (steroid-1-dehydrogenase-producer) were developed by use of mutation selection techniques.
The methods found to be most successful with each species are described. The genealogical relationships within species of a number of strains ofPenicillium chrysogenum, Streptomyces prasinus, andStreptomyces roseochromogenes are presented.
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Thoma, R.W. Use of mutagens in the improvement of production strains of microorganisms. Folia Microbiol 16, 197–204 (1971). https://doi.org/10.1007/BF02884208
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DOI: https://doi.org/10.1007/BF02884208