Abstract
Morphological, cultural and physiological-biochemical properties ofStreptomyces sp. strain 1000 and its antibiotic production were investigated. Antibiotics 1011 (identical with the streptovaricin complex) and 1012 (with antibacterial action) were isolated from the cultural broth of this strain. The overproducing natural variant 1011 was isolated from the population of a strain producing antibiotic 1011 at a concentration of 1000 mg/L (activity of the parent strain represents 41 mg/L only). Comparative taxonomical characteristic ofStreptomyces sp. strain 1000 with strains fromS. spectabilis showed that the strain 1000 differed in some properties and antibiotic production being considered as a new variant ofS. spectabilis. The strain shows an expressed antibiotic activity against G+ as well as G− bacterial and yeasts.
Similar content being viewed by others
References
Bergey’s Manual of Determinative Bacteriology, 8th ed. Williams & Wilkins, Baltimore 1974.
Bondartzev A.S.:Scale of Colour. Acad.Sci. USSR Publ., Moscow 1954.
Gauze G.F., Preobrazhenskaya T.P., Sveshnikova M.A., Terekhova L.P., Maksimova T.S.:Key to Actinomycetes. Nauka Publ. Moscow 1983.
Dietz A., De Boer C., Smith R.M., Siminoff P., Boyack G.A., Whitfield G.B.: Antibiotic streptovaricin and process for its production.US Pat.3 116 202, 1963.
Ivanova V., Vesselinova N., Gesheva R.: Isolation and identification of antibiotic complex 1011 fromStreptomyces sp. 1011.Acta Microbiol.Bulg.21, 47–50 (1987).
Mason D.J., Smith R.M., Dietz A.: Actinospectacin, a new antibiotic. I. Discovery and biological properties.Antibiot.Chemother.11, 118–122 (1961).
Shirling E.B., Gottlieb D.: Methods for characterisation of Streptomyces species.Int.J.Syst.Bacteriol.16, 313–340 (1966).
Vesselinova N., Ivanova V., Gesheva R.: Method for obtaining antibacterial antibiotic.Bulg.Pat.84 704 (1991).
Yamazaki H.: Studies on antimicrobial substance B 44 P (streptovaricin) produced by a strain of actinomycetes.J.Antibiot.21, 204–220 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vesselinova, N., Gesheva, R. & Ivanova, V. Streptomyces species producing the streptovaricin complex. Folia Microbiol 36, 538–541 (1991). https://doi.org/10.1007/BF02884033
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02884033