Abstract
The estrogen receptor binding affinity of 2-phenylindoles is found to be significantly correlated with Kier’s first-order valence molecular connectivity index. The correlation equations obtained provide a much simple rationale to design more potent compounds and help in predicting the potency of new compounds.
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Singh, P. QSAR studies on estrogen receptor binding affinity of 2-phenylindoles using first-order valence molecular connectivity. Proc. Indian Acad. Sci. (Chem. Sci.) 97, 91–95 (1986). https://doi.org/10.1007/BF02880847
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DOI: https://doi.org/10.1007/BF02880847