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Prediction on the binding domain between human interleukin-6 and its receptor

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Abstract

Based on the spatial conformations of human interleukin-6 (hIL-6) derived from nuclear magnetic resonance analysis and human interleukin-6 receptor (hIL-6R) modeled with homology modeling method using human growth hormone receptor as template, the interaction between hIL-6 and its receptor (hIL-6R) is studied with docking program according to the surface electrostatic potential analysis and spatial conformation complement. The stable region structure composed of hIL-6 and hIL-6R is obtained on the basis of molecular mechanism optimization and molecular dynamics simulation. The binding domain between hIL-6 and hIL-6R is predicted theoretically. Furthermore, the especial binding sites that influence the interaction between hIL-6 and hIL-6R are confirmed. The results lay a theoretical foundation for confirming the active regions of hIL-6 and designing novel antagonist with computer-guided techniques.

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Authors and Affiliations

  1. Beijing Basic Medical Institute, Chinese Academy of Military Medical Sciences, 100850, Beijing, China

    Jiannan Feng, Yunfang Ren & Beifen Shen

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  1. Jiannan Feng
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  2. Yunfang Ren
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  3. Beifen Shen
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Correspondence to Jiannan Feng.

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Feng, J., Ren, Y. & Shen, B. Prediction on the binding domain between human interleukin-6 and its receptor. Sci. China Ser. C.-Life Sci. 43, 409–417 (2000). https://doi.org/10.1007/BF02879306

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  • DOI: https://doi.org/10.1007/BF02879306

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