Abstract
Tissue engineering is one exciting approach to treat patients who need a new organ or tissue. A critical element in this approach is the polymer scaffold, as it provides a space for new tissue formation and mimics many roles of natural extracellular matrices. In this review, we describe several design parameters of polymer matrices that can significantly affect cellular behavior, as well as various polymers which are frequently used to date or potentially useful in many tissue engineering applications. Interactions between cells and polymer scaffolds, including specific receptor-ligand interactions, physical and degradation feature of the scaffolds, and delivery of soluble factors, should be considered in the design and tailoring of appropriate polymer matrices to be used in tissue engineering applications, as these interactions control the function and structure of engineered tissues.
Similar content being viewed by others
References
R. Langer and J. P. Vacanti,Science,260, 920 (1993).
D. J. Mooney and A. G. Mikos,Sci. Am.,280, 60 (1999).
B. Alberts, D. Bray, J. Lewis, M. Raff, K. Roberts, and J. D. Watson, “Molecular Biology of the Cell”, p.971, Garland Publishing, New York, 1994.
B.-S. Kim and D. J. Mooney,TIBTECH,16, 224 (1998).
J. J. Marler, J. Upton, R. Langer, and J. P. Vacanti,Adv. Drug Deliv. Rev.,33, 165 (1998).
K. Y. Lee, C. R. Halberstadt, W. D. Holder, and D. J. Mooney in “Principles of Tissue Engineering”, (R. P. Lanza, R. Langer, and J. P. Vacanti Eds.), pp.409–423, Academic Press, San Diego, 2000.
K. S. Anseth, V. S. Shastri, and R. Langer,Nature Biotechnol.,17, 156 (1999).
C. J. Doillon, C. Deblois, M. F. Cote, and N. Fournier,Mat. Sci. Eng. C-Biomim.,2, 43 (1994).
D. J. Mooney, M. D. Breuer, K. McNamara, J. P. Vacanti, and R. Langer,Tissue Eng.,1, 107 (1995).
W. H. Wong and D. J. Mooney in “Synthetic Biodegradable Polymer Scaffolds”, (A. Atala and D. J. Mooney Eds.), pp.49–80, Birkhäuser Press, Boston, 1997.
D. J. Mooney, D. F. Baldwin, N. P. Suh, J. P. Vacanti, and R. Langer,Biomaterials,17, 1417 (1996).
L. D. Harris, B.-S. Kim, and D. J. Mooney,J. Biomed. Mater. Res.,42, 396 (1998).
M. E. Sheridan, L. D. Shea, M. C. Peters, and D. J. Mooney,J. Control. Rel.,64, 91 (2000).
W. L. Murphy, M. C. Peters, D. H. Kohn, and D. J. Mooney,Biomaterials,21, 2521 (2000).
H. Lo, M. S. Ponticiello, and K. W. Leong,Tissue Eng.,1, 15 (1995).
K. Whang, C. H. Thomas, K. E. Healy, and G. Nuber,Polymer,36, 837 (1995).
L. E. Freed, G. Vunjak-Novakovic, R. J. Biron, D. B. Eagles, D. C. Lesnoy, S. K. Barlow, and R. Langer,Bio/Technology,12, 689 (1994).
B.-S. Kim and D. J. Mooney,J. Biomed. Mater. Res.,41, 322 (1998).
A. J. Domb, C. F. Gallardo, and R. Langer,Macromolecules,22, 3200 (1989).
E. M. Pinholt, E. Solheim, G. Bang, and E. Sudmann,J. Oral Maxillofac. Surg.,50, 1300 (1992).
T. J. Deming,Nature,390, 386 (1997).
J. P. O’Brien,Trends Polym. Sci.,8, 228 (1993).
W. A. Petka, J. L. Harden, K. P. McGrath, D. Wirtz, and D. A. Tirrell,Science,281, 389 (1998).
K. H. Bouhadir, G. M. Kruger, K. Y. Lee, and D. J. Mooney,J. Pharm. Sci.,89, 910 (2000).
G. Klock, A. Pfeffermann, C. Ryser, P. Grohn, B. Kuttler, H. J. Hahn, and U. Zimmermann,Biomaterials,18, 707 (1997).
K. Y. Lee and D. J. Mooney,Chem. Rev., in press.
W. R. Gombotz and S. F. Wee,Adv. Drug Deliv. Rev.,31, 267 (1998).
P. Eiselt, J. Yeh, R. K. Latvala, L. D. Shea, and D. J. Mooney,Biomaterials,21, 1921 (2000).
K. Y. Lee, E. Alsberg, and D. J. Mooney,J. Biomed. Mater. Res.,56, 228 (2001).
T. Chandy and C. P. Sharma,Biomater. Artif. Cells Artif. Organs,18, 1 (1990).
K. Tomihata and Y. Ikada,Biomaterials,18, 567 (1997).
Y. M. Elcin, V. Dixit, K. Lewin, and G. Gitnick,Artif. Organs,23, 146 (1999).
Y. M. Lee, Y. J. Park, S. J. Lee, Y. Ku, S. B. Han, S. M. Choi, P. R. Klokkevold, and C. P. Chung,J. Periodontol.,71, 410 (2000).
A. M. Afify, M. Stern, M. Guntenhoner, and R. Stern,Arch. Biochem. Biophys.,305, 434 (1993).
Q. Ye, G. Zund, P. Benedikt, S. Jockenhoevel, S. P. Hoerstrup, S. Sakyama, J. A. Hubbell, and M. Turina,Eur. J. Cardio-Thorac. Surg.,17, 587 (2000).
Y. Ikari, K. Fujikawa, K. O. Yee, and S. M. Schwartz,J. Biol. Chem.,275, 12799 (2000).
J. Meinhart, M. Fussenegger, and W. Hobling,Ann. Plast. Surg.,42, 673 (1999).
S. Pulapura and J. Kohn,J. Biomater. Appl.,6, 216 (1992).
K. P. Vercruysse, D. M. Marecak, J. F. Marecek, and G. D. Prestwich,Bioconjugate Chem.,8, 686 (1997).
B. Chevallay, N. Abdul-Malak, and D. Herbage,J. Biomed. Mater. Res.,49, 448 (1999).
R. O. Hynes,Cell,69, 11 (1992).
K. Smentana,Biomaterials,14, 1046 (1993).
J. A. Rowley, G. M. Madlambayan, and D. J. Mooney,Biomaterials,20, 45 (1999).
S. Huang and D. E. Ingber,Nature Cell. Biol.,1, E131 (1999).
Y. L. Cao, J. P. Vacanti, K. T. Paige, J. Upton, and C. A. Vacanti,Plast. Reconstr. Surg.,100, 297 (1997).
P. Eiselt, K. Y. Lee, and D. J. Mooney,Macromolecules,32, 5561 (1999).
K. Y. Lee, J. Rowley, E. Moy, K. H. Bouhadir, and D. J. Mooney,Macromolecules,33, 4291 (2000).
K. H. Bouhadir, K. Y. Lee, E. Alsberg, K. L. Damm, K. W. Anderson, and D. J. Mooney,Biotechnol. Prog, in press.
A. Al-Shamkhani and R. Duncan,J. Bioact. Compat. Polym.,10, 4 (1995).
K. H. Bouhadir, D. Haussman, and D. J. Mooney,Polymer,40, 3575 (1999).
K. Y. Lee, K. H. Bouhadir, and D. J. Mooney,Macromolecules,33, 97 (2000).
D. J. Mooney, K. Sano, P. M. Kaufmann, K. Majahod, B. Schloo, J. P. Vacanti, and R. Langer,J. Biomed. Mat. Res.,37, 413 (1997).
J. E. Nor, J. Christensen, D. J. Mooney, and P. J. Polverini,Am. J. Pathology,154, 375 (1999).
J. Bonadio,Adv. Drug Deliv. Rev.,44, 185 (2000).
M. C. Peters, B. C. Isenberg, J. A. Rowley, and D. J. Mooney,J. Biomat. Sci. Polym. Ed.,9, 1267 (1999).
K. Y. Lee, M. C. Peters, K. W. Anderson, and D. J. Mooney,Nature,408, 998 (2000).
K. Y. Lee, M. C. Peters, and D. J. Mooney,Adv. Mater.,13, 837 (2001).
R. Langer,Science,249, 1527 (1992).
L. D. Shea, E. Smiley, J. Bonadio, and D. J. Mooney,Nature Biotechnol.,17, 551 (1999).
B.-S. Kim, J. Nikolovski, J. Bonadio, and D. J. Mooney,Nature Biotechnol.,17, 979 (1999).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lee, K.Y., Mooney, D.J. Cell-interactive polymers for tissue engineering. Fibers Polym 2, 51–57 (2001). https://doi.org/10.1007/BF02875258
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02875258