Abstract
The species most frequently found in the group of neonates wasC. parapsilosis, its incidence reaching 48%. Other yeasts isolated from blood wereC. albicans (41%),C. tropicalis (7%),C. krusei andC. pseudotropicalis (2% each). Six yeast species (C. albicans 44%,C. parapsilosis 28%,C. tropicalis 11%,C. krusei 8%,C. guilliermondii 6%,C. lusitaniae 3%) were detected in cancer patients. The presence of an intravenous catheter as a possible risk in the development of candidaemia was identified in all neonates and in 69% of cancer patients.C. krusei candidaemia was associated with prophylactic fluconazole therapy.
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Abi-Said D., Anaissie E., Uzun O., Raad I., Pinzcowski H., Vartivarian S.: The epidemiology of hematogenous candidiasis caused by differentCandida species.Clin. Infect. Dis.24, 1122–1128 (1997).
Anaissie E.J., Rex J.H., Uzun Ö, Vartivarian S.: Predictors of adverse outcome in cancer patients with candidemia.Am. J. Med.104, 238–245 (1998).
Berrouane Y.F., Hollis R.J., Pfaller M.A.: Strain variation among and antifungal susceptibilities of isolates ofCandida krusei.J. Clin. Microbiol.34, 1856–1858 (1996).
Branchini M.L., Pfaller M.A., Rhine-Chalberg J., Frempong T., Isenberg H.D.: Genotypic variation and slime production among blood and catheter isolates ofCandida parapsilosis.J. Clin. Microbiol.32, 452–456 (1994).
Dorko E., Ďurovičová J.: Possibilities of laboratory diagnosis of oral candidosis.Stomatológ7, 5–7 (1997).
Dorko E., Kmeťová M., Dorko F.: Analysis of the occurrence ofCandida krusei and its resistance to antimycotics.Remedia Klin. Mikrobiol.3, 221–224 (1999a).
Dorko E., Kmeťová M., Ďurovičová J., Dorko F.: Candidosis in neonates.Čs. Pediatr.54, 349–353 (1999b).
Dorko E., Kmeťová M., Ďurovičová J., Dorko F.: CHROMagarCandida—a new means for the identification of yeasts.Remedia Klin. Mikrobiol.3, 74–76 (1999c).
Dorko E., Kmeťová M., Marossy A., Dorko F., Molokáčová M.: Non-albicans Candida species isolated from plastic devices.Mycopathologia148, 117–122 (1999d).
Dorko E., Kmeťová M., Dorko F., Bračoková I., Marossy A., Škardová I.: Non-albicans Candida species in cancer patients.Pak. J. Biol. Sci., in press (2000a).
Dorko E., Kmeťová M., Dorko F., Škardová I.: Incidence ofCandida tropicalis in clinical samples over 5-year period.Pak. J. Biol. Sci.4, 606–609 (2000b).
Dorko E., Kmeťová M., Pilipčinec E., Bračoková I., Dorko F., Danko J., Švický E., Tkáčiková L'.: Rare non-albicans Candida species detected in different clinical diagnoses.Folia Microbiol.45, 364–368 (2000c).
Fowler S.L., Rhoton B., Springer S.C., Messer S.A., Hollis R.J., Pfaller M.A.: Evidence for person-to-person transmission ofCandida lusitaniae in a neonatal intensive care unit.Infect. Control. Hosp. Epidemiol.19, 343–345 (1998).
Fraser V.J., Jones M., Dunkel J., Storfer S., Medoff G., Dunagan W.G.: Candidemia in a tertiary care hospital: epidemiology, risk factors and predictors of mortality.Clin. Infect. Dis.15, 414–421 (1992).
Iwen P.C., Kelly D.M., Reed E.C., Hinrichs S.H.: Invasive infection due toCandida krusei in immunocompromised patients not treated with fluconazole.Clin. Infect. Dis.20, 342–347 (1995).
Kossoff E.H., Buescher E.S., Karlowicz M.G.: Candidemia in a neonatal intensive care unit: trends during fifteen years and clinical features of 111 cases.Pediatr. Infect. Dis. J.17, 504–508 (1998).
Král'ovičová K., Špánik S., Oravcová E., Mrázová M., Mórová E., Gulíková V., Kukučková E., Koreň P., Pichna P., Nogová J., Kunová A., Trupl J., Krčméry V.: Fungemia in cancer patients undergoing chemotherapyversus surgery: risk factors, etiology and outcome.Scand. J. Infect. Dis.29, 301–304 (1997).
Krčméry V., Oravcová E., Špánik S., Mrázová-Studená M., Trupl J., Kunová A., Stopková-Grey K., Kukučková E., Krupová I., Demitrovičová A., Král'ovičová K.: Nosocomial breakthrough fungemia during antifungal prophylaxis or empirical antifungal therapy in 41 cancer patients receiving antineoplastic chemotherapy: analysis of etiology risk factors and outcome.J. Antimicrob. Chemother.41, 373–380 (1998a).
Krčméry V., Špánik S., Grausová S., Trupl J., Krupová I., Roidová A., Šálek T., Šufliarsky J., Mardiak J.:Candida parapsilosis fungemia in cancer patients—incidence, risk factors and outcome.Neoplasma45, 336–342 (1998b).
Launay O., Lortholary O., Bouges-Michel C.: Candidemia: a nosocomial complication in adults with late-stage AIDS.Clin. Infect. Dis.26, 1134–1141 (1998).
Nucci M., Colombo A.L., Silveira F., Richtmann R., Salomao R., Branchini M.L., Spector N.: Risk factors for death in patients with candidemia.Infect. Control Hosp. Epidemiol.19, 846–850 (1998a).
Nucci M., Silveira M.I., Spector N., Silveira F., Velasco E., Martins C.A., Derossi A., Colombo A.L., Pulcheri W.: Fungemia in cancer patients in Brazil: predominance of non-albicans species.Mycopathologia141, 65–68 (1998b).
Odds F.C., Bernaerts R.: CHROMagarCandida, a new differential isolation medium for presumptive identification of clinically importantCandida species.J. Clin. Microbiol.32, 1923–1929 (1994).
Rangel-Frausto M.S., Wiblin T., Blumberg H.M., Saiman L., Patterson J., Rinaldi M., Pfaller M., Edwards J.E., Jarvis W., Dawson J., Wenzel R.P.: National epidemiology of mycoses survey (NEMIS): variations in rates of bloodstream infections due toCandida species in seven surgical intensive care units and six neonatal intensive care units.Clin. Infect. Dis.29, 253–258 (1999).
Sandven P.: Laboratory identification and sensitivity testing of yeast isolates.Acta Odontol. Scand.48, 27–36 (1990).
Saxen H., Virtanen M., Carlson P., Hoppu K., Pohjavuori M., Vaara M., Vuopio-Varkila J., Peltola H.: NeonatalCandida parapsilosis outbreak with a high case fatality rate.Pediatr. Infect. Dis. J.14, 776–781 (1995).
Singh K., Chakrabarti A., Narang A., Gopalan S.: Yeast colonization and fungemia in preterm neonates in a tertiare care centre.Indian J. Med. Res.110, 169–173 (1999).
Stamos J.K., Rowley A.H.: Candidemia in a pediatric population.Clin. Infect. Dis.20, 571–575 (1995).
Tomšíková A.: New yeast pathogens—agents of nosocomial mycoses.Folia Microbiol.44, 118 (1999).
Voss A., Le Noble J.L.M.L., Verduyn Lunel F.M., Foudraine N.A., Meis J.F.G.M.: Candidemia in intensive care unit patients: risk factors for mortality.Infection25, 8–11 (1997).
Weems J.J., Chamberland M.E., Ward J., Willy M., Padhye A.A., Solomon S.L.:Candida parapsilosis fungemia associated with parenteral nutrition and contaminated blood pressure transducers.J. Clin. Microbiol.25, 1029–1032 (1987).
Wingard J.R.: Importance ofCandida species other thanC. albicans as pathogens in oncology patients.Clin. Infect. Dis.20, 115–125 (1995).
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Trubenová, D., Virágová, S., Pilipčinec, E. et al. Candidaemia in cancer patients and in children in a neonatal intensive care unit. Folia Microbiol 46, 161–164 (2001). https://doi.org/10.1007/BF02873597
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DOI: https://doi.org/10.1007/BF02873597