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Role of prostaglandin in the regulation of gastric H+—Transporting system

  • Prostaglandins
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Abstract

Prostaglandins and (PG) have been reported to be an important gastric acid suppressive factor. However, the mechanism underlying is yet to be clearly established. In vitro study with gastric microsomes in presence of both PGE2 and PGI2 shows a stimulation of gastric H+ K+-ATPase activity below 1X10−6M and 2.5X10−7M concentrations respectively. However, with further increase in concentrations of both PGE2 and PGI2, H+, K+-ATPase activity shows an inhibition but PGI2 completely obliterates the K+ stimulated part of H+, K+-ATPase activity at higher concentration. The H+-ion transport study using chambered frog gastric mucosa shows that both PGE2 and PGI2 inhibit H+-ion transport at 5X10−6 M and 10X10−6M concentrations respectively but the effect of PGI2 is reversible. These differential effects of PGE2 and PGI2 on microsomal H+, K+-ATPase and on H+ transport my be caused by the differential effects of these phospholipid mediators with the gastric mucosal cell membrane. This in vitro investigation shows the role of prostaglandin (s) as a physiological switch/regulator of gastric H+ ion transport leading to the cessation of gastric acid secretion.

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Authors and Affiliations

  1. Department of Biochemistry, University College of Medicine, Calcutta University, 244B, Acharya J.C. Bose Road, 700020, Calcutta

    Babul Bandyopadhyay & Sandip K Bandyopadhyay

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  1. Babul Bandyopadhyay
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  2. Sandip K Bandyopadhyay
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Bandyopadhyay, B., Bandyopadhyay, S.K. Role of prostaglandin in the regulation of gastric H+—Transporting system. Indian J Clin Biochem 13, 41–45 (1998). https://doi.org/10.1007/BF02873442

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