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Serum lipid profile in patients with acute myocardial infarction

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Abstract

Serum lipids and lipoproteins were estimated in 29 patients with acute myocardial infarction during acute phase (day 1,2,3), predischarge and after three months. Serum total lipids, total cholesterol (TC) and LDL-cholesterol (LDLc) showed no significant change during the hospital stay and three months followup. HDL-cholesterol (HDLc), however, started falling from day 2 onwards with statistically significant reduction at pre-discharge and remained so at 3 months. The ratios of TC/HDLc and LDLc/HDLc showed significant increase on predischarge day as compared to day 1. Serum triglycerides also showed an increasing trend after myocardial infarction with a significant increase on day 3 and predischarge as compared to day 1. it is concluded that the optimum time for assessment of serum lipid profile in patients with myocardial infarction seems to be within 24 hours of the acute episode.

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References

  1. Biorch, G., Blomquist, G. and Sievers, J. (1957) Cholesterol values in patients with myocardial infarction and normal control group. Acta. Med. Scand. 156,493–497.

    Google Scholar 

  2. Bjorntrop, P. and Malmcrone, R. (1960) Serum cholesterolin patient with myocardial infarction in younger ages. Acta. Med. Scand. 168,151–155.

    Google Scholar 

  3. Dodds, C. and Mills, G.L. (1959) Influence of myocardial infarction on plasma lipoprotein concentration. Lancet i, 1160–1163.

    Article  Google Scholar 

  4. Tibblin, G. and Cramer, K. (1963) Serum lipids during the course of acute myocardial infarction and one year afterwards. Acta Med. Scand. 174, 451–455.

    PubMed  CAS  Google Scholar 

  5. Fyfe, T., Baxter, R.H., Cochran, K.M. and Booth, E.M. (1971) Plasma lipid changes after myocardial infarction. Lancet ii, 997–1001.

    Article  Google Scholar 

  6. Kirkeby, K. (1972) Disturbances in serum lipids and in their fatty’ acid composition following acute myocardial infarction. Acta. Med. Scand. 192,523–528.

    PubMed  CAS  Google Scholar 

  7. Avogaro, A., Bittilin Bon, G., Cazzalato, C., Quinci, G. B., Sparla, H. and Zagatti, G.C. (1978). Variations in apolipoproteins B and A during the course of myocardial infarction. Eur. J. Clin. Invest. 8,121–129.

    Article  PubMed  CAS  Google Scholar 

  8. Ballantyne, F.C., Melville, D.A., Mc Kenna, J.P., Morrison, B.A. and Ballantyne, D. (1979) Response of plasma lipoproteins and acute phase proteins to myocardial infarction. Clin. Chim. Acta 99,85–92.

    Article  PubMed  CAS  Google Scholar 

  9. Ryder, R.E.J., Hayes, T.M., Mulligan, I.P., Kingswood, J.C., Williams, S. and Owens, D.R. (1984) How soon after myocardial infarction should plasma lipid values be assessed? Br. Med. J. 289, 1651–1653.

    CAS  Google Scholar 

  10. Jackson, R., Scragg, R., Marshall, R., White, O’Brien, K. and Small, C. (1987) Changes is serum lipid concentrations during first 24, hours after myocardial infarction. Br. Med. J. 294, 1588–1589.

    CAS  Google Scholar 

  11. Heldenburg, D., Rubenstein, A., Levtov, O., Berns, L., Werbin, B. and Tamir, L. (1980) Serum lipids and lipoprotein concentrations during the acute phase of myocardial infarction. Atherosclerosis 35, 433–437.

    Article  Google Scholar 

  12. Fredrickson, D.S. (1969) The role of lipids in acute myocardial infarction. Circulation 39,Suppl. IV-99-IV-III.

  13. Swedarsen, M., Vythilingum, S., Jialal, I. and Nadar, R. (1988). Plasma lipids can be reliably assessed within 24 hours after acute myocardial infarction. Postgrad. Med. J. 64, 352–356.

    Google Scholar 

  14. Buckley, B.M. and Bold, A.M. (1982) Managing hyperlipidaemias. Br. Med. J. 285, 1293–1294.

    CAS  Google Scholar 

  15. Watson, W.C., Buchman, K.D. and Dickson, C. (1963) Serum cholesterol levels after myocardial infraction. Br. Med. J. 2, 709–712.

    Article  PubMed  CAS  Google Scholar 

  16. Schlant, R.C. and Digirolamo, M. (1978) Modification of risk factor in the prevention and management of coronary atherosclerotic heart disease: The Heart, 4th Ed., Hurst J.W., Logue R.B., Schlant R.C., Wenger N.K., New York: McGraw Hill Book Co., p 1311–1344.

    Google Scholar 

  17. Zollner, N. and Kirsch, K. (1962) Absorptimetric determination of total lipids in serum. Z. Ges. Exp. Med. 135, 544–549.

    Article  Google Scholar 

  18. Friedewald, W.T., Levy, R.I. and Fredrickson, D.S., (1972) Estimation of the concentration of low-density lipoprotein cholesterol plasma without use of the preparative ultracentrifuge. Clin. Chem. 18, 499–502.

    PubMed  CAS  Google Scholar 

  19. Berlin, R., Oldfelt, C.O. and Vikrot, O. (1969) Acute myocardial infraction and plasma phospholipid levels. Acta Med. Scand. 185, 439–442.

    PubMed  CAS  Google Scholar 

  20. Dyerberg, J., Bang, H.O. and Neilsen, J.A. (1970) Plasma lipids and lipoproteins in patients with myocardial infraction and in a control material. Acta Med. Scand. 187, 353–359.

    PubMed  CAS  Google Scholar 

  21. Glomset, J.A. (1968) The plasma lecithin: cholesterol acyltransferase reaction. J. Lipid Res. 9, 155–167.

    PubMed  CAS  Google Scholar 

  22. Natio, H.K. (1985). The association of serum-lipids, lipoproteins and apolipoproteins with coronary artery disease assessed by coronary arteriography. Ann. N. Y. Acad. Sci. 454, 230–238.

    Article  Google Scholar 

  23. Vetter, N.J., Adams, W., Strange, R.C. and Oliver, M.F. (1974) Initial metabolic and hormonal response to acute myocardial infarction. Lancet i, 284–289.

    Article  Google Scholar 

  24. Zampogna, A., Luria, M.H., Mancibens, S.J. and Luria, M.A. (1980) Relationship between lipids and occlusive coronary disease. Arch. Intern. Med. 140, 1067–1069.

    Article  PubMed  CAS  Google Scholar 

  25. Luria, M.H., Erel, J., Sapoznikov, D., Gotsman, M.S. (1991) Cardiovascular risk factor clustering and ratio of total cholesterol to high-density lipoprotein cholesterol in angiographically documented coronary artery disease. Am. J. Cardiol 67, 31–36.

    Article  PubMed  CAS  Google Scholar 

  26. Pfohl, M., Schreiber, I, Liebich, H.M., Hairing, H.U. and Haffmeister, H.M. (1999) Upregulation of cholesterol synthesis after acute myocardial infarction-is cholesterol a positive acute phase reactant? Atherosclerosis 142, 389–393.

    Article  PubMed  CAS  Google Scholar 

  27. Clucas, A. and Miller, N. (1988) Effects of Acebutolol on the serum lipid profile. Drugs 36 (suppl.2), 41–50.

    Article  PubMed  Google Scholar 

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Nigam, P.K., Narain, V.S. & Hasan, M. Serum lipid profile in patients with acute myocardial infarction. Indian J Clin Biochem 19, 67–70 (2004). https://doi.org/10.1007/BF02872393

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