Abstract
This open-label, prospective study assessed the efficacy and safety of topical ketanserin gel in 63 patients with symptomatic anal fissure. The efficacy outcome was total clinical healing of the fissure. Topical ketanserin gel was 90% effective (fissure healed) and 100% safe (no adverse events) in the primary nonsurgical treatment of anal fissure.
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References
DeCree J, Veerhaefen H, Symoens J. Acute blood-pressure lowering effect of ketanserin.Lancet. 1981; 1: 1161–1162.
Janssens M, Symoens J, Robertson MP. Ketanserin in the treatment of peripheral vascular disease or hypertension in patients with diabetes mellitus: a review.J Cardiovasc Pharmacol. 1991; 17(suppl 5): S54-S66.
Apelqvist J, Castenfors J, Carson J, et al. Ketanserin in the treatment of diabetic foot ulcer with severe peripheral vascular disease.Int Angiol. 1990; 9: 120–124.
Rooman RP, Janssen H. Ketanserin promotes wound healing: clinical and preclinical results.Prog Clin Biol Res. 1991; 365: 115–128.
Roelens P. Double-blind, placebo-controlled study with topical 2% ketanserin ointment in the treatment of venous ulcers.Dermatologica. 1989; 178: 98–102.
Janssen PA, Janssen H, Cauwenberg G, et al. Use of topical ketanserin in the treatment of skin ulcers: a double-blind study.J Am Acad Dermatol. 1989; 21: 85–90.
Lund JN, Scholefield JH. Aetiology and treatment of anal fissure.Br J Surg. 1996; 83: 1335–1344.
Rosen L, Abel ME, Gordon PH, et al. Practice parameters for the management of anal fissure.Dis Colon Rectum. 1992; 35: 206–208.
Corman MC. Anal fissure. In:Colon and Rectal Surgery. 4th ed. Philadelphia, Pa: Lippincott-Raven; 1998: 206–223.
Fleshman JW. Fissure-in-ano and anal stenosis. In: Beck DE, Wexner SD, eds.Fundamentals of Anorectal Surgery. 2nd ed. London: WB Saunders; 1998: 209–294.
Wong WD. Incontinence after lateral internal sphincterotomy: anatomical and functional evaluation.Dis Colon Rectum. 1998; 41: 425–427.
Khubchandani IT, Reed JF. Sequelae of internal sphincterotomy for chronic fissure in ano.Br J Surg. 1989; 76: 431–434.
Jost WJ, Schimrigk K. Therapy of anal fissure using botulin toxin.Dis Colon Rectum. 1994; 37: 1321–1324.
Gui D, Cassetta E, Anastasio G, Bentivoglio AR, Maria G, Albanese A. Botulinum toxin for chronic anal fissure.Lancet. 1994; 344: 1127–1128.
Loder PB, Kamm MA, Nicholls RJ, Phillips RK. “Reversible chemical sphincterotomy” by local application of glyceryl trinitrato.Br J Surg. 1994; 81: 1386–1389.
Gorfine SR. Topical nitroglycerin therapy for anal fissures and ulcers.N Engl J Med. 1995; 333: 1156–1157.
Maria G, Cassetta E, Gui D, Brisinda G, Bentivoglio AR, Albanese A. A comparison of botulinum toxin and saline for the treatment of chronic anal fissure.N Engl J Med. 1998; 338: 217–220.
Lund JN, Armitage NC, Scholefield JH. Use of glyceryl trinitrate ointment in the treatment of anal fissure.Br J Surg. 1996; 83: 776–777.
Watson SJ, Kamm MA, Nicholls RJ, Phillips RKS. Topical glyceryl trinitrate in the treatment of chronic anal fissure.Br J Surg. 1996; 83: 771–775.
Maria G, Brisinda G, Bentivoglio AR, Cassetta E, Gui D, Albanese A. Botulinum injections in the internal anal sphincter for the treatment of chronic anal fissure: long-term results after two different dose regimens.Ann Surg. 1998; 228: 664–669.
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Zielanowski, M.M. Topical ketanserin gel for anal fissure: An open-label, prospective study. Adv Therapy 17, 27–31 (2000). https://doi.org/10.1007/BF02868028
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DOI: https://doi.org/10.1007/BF02868028