Abstract
The levels of total sialic acid, lipid bound sialic acid and fucose were estimated in the sera of patients with benign and malignant tumours of breast. An increase was noted in all the three parameters, with a more marked increase in malignancy, when compared with benign and controls. Consequent to surgery, there was an elevation in the serum levels of the above parameters than the values prior to surgery and a decline was noted two months after surgery although none of the values reached the normal range. These results suggest a close association of the glycoproteins with the tumour burden and further signify their role in early detection and staging of cancer breast.
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Ephross, S.A., Morris, D.L. and Hulka, B.S. (1990) Increases in breast cancer incidence and mortality rates between 1975 and 1986 in white and black Americans, a screening effect or an alarming trend? Am. J. Epidemiol 132, 790 (Abstract).
Blot, W.J., Devessa, S.S. and Fraumeni, J.F. Jr. (1987) Declining breast cancer mortality among young American women. J. Natl. Cancer Inst. 78, 451–454.
Tretli, S., Haldorsen, T. and Otlestad, L. (1990) The effect of premorbid height and weight on the survival of breast cancer patients. Br. J. Cancer 62, 299–303.
Chan, P.C. and Dao, T.L. (1983) Effect of dietary fat on age dependent sensitivity to mammary carcinogenesis. Cancer Letts. 18, 145–149.
Parazzini, F., Lavecchia and Negi, E. (1993) Life long menstrual pattern and risk of breast cancer. Oncology 50, 22–25.
Fwertz, M., Duffy, S.W. and Adami, H.O. (1990) Age at first birth, parity and risk of breast cancer a meta analysis of 8 studies from Nordic countries. Intl. J. Cancer 46, 597–603.
Brinton, A.L., Potischman, A.N. and Swanson, C.A. (1995) Breast feeding and breast cancer risk. Cancer Causes and Control 6, 199–208.
Korenman, S.G. (1980) The endocrinology of breast cancer. Cancer, 46, 874–878.
Kubba, S.V., Weber, W. and Mehta, J.P. (1993) Familial occurrence of cancer in Basla city. Intl. J. Cancer, 30, 100–108.
Lipton, A. and Harvey, H.A. (1979) Glycoproteins and human cancer; circulating levels in cancer serum. Cancer 43, 1766–1771.
Nigam, B., Joshi, S.P., Nagar, S., Chavan, R. and Pendharkar, D. (1996) Some biochemical markers in various neoplasms. A multivariate analysis. Ind. J. Clin. Biochem. 11, 124–128.
Warren, L. (1959) The thiobarbituric acid assay of sialic acid. J. Biol. Chem. 234, 1971–1975.
Katopodis, N. (1980) Improved method to determine lipid bound sialic acid in plasma or serum. Res. Commun. Chem. Pathol. Pharmacol. 30, 171–180.
Dische, Z. and Shettles, L.B. (1955) Determination of serum glycoprotein. In Methods of Biochemical analysis, 2nd ed., Vol. 2, Inter Science Publ., New York, p 279–311.
Morre, J., Kloppe, L.M. and Merrit, W.D. (1978) Glycolipids as indicator of tumorigenesis. J. Supramol. Struct. 9, 157–177.
Plucinsky, M.C., Riley, W.M., Prorok, J.J. and Alhadeff, J.A. (1986) Total and lipid associated serum sialic acid levels in cancer with different sites and different degrees of metastatic involvement. Cancer 58, 2680–2685.
Patel, P.S., Raval, G.N. and Rawal, R.R. (1994) Assessing benefits of combining bio-chemical and immunological markers in patients with cancer. Cancer Letts. 82, 129–133.
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Varkey, M., Devi, R.S. & Rao, S.B. Glycoprotein components in the serum of patients with cancer breast. Indian J Clin Biochem 12, 63–66 (1997). https://doi.org/10.1007/BF02867958
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DOI: https://doi.org/10.1007/BF02867958