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Status of epidermal growth factor receptors family in hormone-dependent carcinomas of the breast and prostate with reference to serum lipids and lipoproteins

  • Cancer
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Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

There are numerous growing evidences of resemblance between carcinomas of the breast and prostate. A total of 45 cases of these two hormone-dependent cancers along with appropriate controls were subjected for status of epidermal growth factor receptors as well as serum lipid profile. Paraffin embedded tissue sections from aforesald tumours were analysed by immunohistochemical staining for epidermal growth factor receptor (EGF-R), c-erbB-2 oncoprotein, estrogen receptor (ER) and progesterone receptor (PgR). Sera from same individuals were studied for serum lipid profile analysis. The study revealed that immunoexpression of all receptor proteins (EGF-R). c-erbB-2 was significantly higher in breast carcinoma. In addition, mean levels of triglycerides, total cholesterol, LDL-cholesterol were found to be significantly elevated while the level of HDL-cholesterol was observed to be lower among patients with breast cancer as compared to matched controls. Further, ER-positive breast cancer cases have significantly higher mean level of HDL-cholesterol when compared with ER-negative breast cancer patients. Contrary to this, no alteration in different serum lipid fractions was noticed among the patients with prostate cancer. However, a positive relationship was noticed between immunoexpressions of EGF-R and c-erbB-2 in prostate cancer.

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Authors and Affiliations

  1. Department of Radiotherapy, Maulana Azad Medical College, Bahadur Shah Zafar Marg, 110002, New Delhi

    D. Jain & A. K. Bahadur

  2. Institute of Cytology and Preventive Oncology (ICMR), Maulana Azad Medical College, Bahadur Shah Zafar Marg, 110002, New Delhi

    A. Ray, S. Sharma, S. L. D. Naik & B. K. Sharma (Deputy Director)

  3. Department of Pathology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, 110002, New Delhi

    K. U. Chaturvedi

  4. Department of Surgery, Dr.Ram Manohar Lohia Hospital, 110001, New Delhi

    R. Sood

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  1. D. Jain
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  4. K. U. Chaturvedi
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  7. S. L. D. Naik
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  8. B. K. Sharma
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Jain, D., Ray, A., Bahadur, A.K. et al. Status of epidermal growth factor receptors family in hormone-dependent carcinomas of the breast and prostate with reference to serum lipids and lipoproteins. Indian J Clin Biochem 16, 42–51 (2001). https://doi.org/10.1007/BF02867567

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