Abstract
1-Aryl-4-arylidene-2-oxazoline-5-ones (I) and the corresponding unsaturated amidoesters (II) and arylidene hypuric acid hydrazide (III) were obtained. The hydrazides and 1-aryl-1,3-dithiophenol-2-amidopropan-3-ones derivatives (IV) were also obtained. The derivatives were tested for their antibacterial, activities.
Similar content being viewed by others
Literature Cited
Werner W.: The pharmacology of analgesic antipyretic compound preparations, Deut. Dentist z-5, 423–6 (1951).
Bharmaria, R.P. Bellare, R.A., and Deliwala, C.V.: In vitro effect of 1-acyl-4-alkyl (or aryl)-thiosemicarbazides, 1-(5-chlorosalicylidine)-4-alkyl (or aryl) thiosemicarbazones, and some hydrazones of 5-chloro-salicylaldehyde against pathogenic bacteria, including Mycobacterium tuberculosis (H 37 RV).Indian J. Exp. Biol. 6, 62 (1968).
Yackenstrdt, A. and Slark, A.: Synthesis and π electronic structure of 2,5-bis (alkylamino) tetraphthalic acid diethyl esters.Microbiol. 17, 69 (1977).
Bellamy L.J.: The Infra-red spectra of complex organic molecules. 2nd ed. Wiley, New York (1958).
Vigneaud, v-Du and Mayer, C.U.: The temporary formation of the azalactone ring in the racemization of acyl derivatives of amino acids with acetic anhydride.J. Biol. Chem. 99, 143 (1932).
Iyengar, D.SC, Prassad, K.K. and Venkataratnain R.V.: 1-Heteroaryl pyrazoles. Stabilization of the 5-hydroxy toutomeric from by an-nitrogen atom and effect on spectral properties.Aus. J. Chem. 27, 2349 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Moharram, H.H., El-Amin, S.A. Synthesis of new oxazolin-5-ones derivatives as antibacterial agents. Arch. Pharm. Res. 11, 175–180 (1988). https://doi.org/10.1007/BF02861306
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02861306