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Issues within Keratinocyte Growth Factor (KGF) research

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Abstract

As the seventh member of Fibroblast Growth Factor (FGF) family, Keratinocyte Growth Factor (KGF or FGF-7) is observed to mediate epithelial cell proliferation and differentiation in a variety of tissues. In this article, such following issues within KGF research were reviewed, as (1) KGF functioning pathways: experimental results demonstrated the paracrine pathway of KGF played main role in mesenchymal-epithelial interactions whereas KGF itself was under the control of a feedback regulation, autocrine provided KGF alternative functioning way particularly in tumourogenesis; (2) KGF in apoptosis: a few of investigations recently illustrated KGF mediated cell survival was based on its mitogenic function via stimulating cell growth, moreover KGF could inhibit the ROS-induced apoptosis through Nrf-2 pathway; (3) KGF during tumourogenesis: high expression of KGF enhanced progression, motility and invasiveness of tumor cells and various cancers, in company with paracrine loop replaced by autocrine loop, meanwhile KGF clearly played the early signal in the progression of breast cancer; (4) Medical application and administration of KGF: KGF had been successfully used in several preclinical models of radiation and chemotherapy-induced mucositis, and developed into commercial medicine (i.e. Palifermin), however more effective delivery systems are still under trial.

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References

  • Abraham, J.A. and Klagsbrun, M. 1996. Modulation of wound repair by members of the fibroblast growth factor family [M]. In: Clark, R.A.F. (Ed.), The molecular and cellular biology of woundrepair. 2nd edition. Plenum Press, pp. 195–248.

  • Alpdogan, O., Hubbard, V.M., Muriglan, S.J.,et al. 2005. Keratinocyte growth factor (KGF) is required for post-natal thymic regeneration [J]. Biology of Blood and Marrow Transplantation,11(2): 57 (Supplement 1).

    Article  Google Scholar 

  • Andreadis, S.T., Hamoen, K.E., Yarmush, M.L.,et al. 2000. Keratinocyte growth factor induces hyperproliferation and delays differentiation in a skin equivalent model system [J]. FASEB J.,15(6): 898–906.

    Article  Google Scholar 

  • Auf dem Keller, U., Krampert, M., Kümin, A.,et al. 2004. Keratinocyte growth factor: effects on keratinocytes and mechanisms of action [J]. European Journal of Cell Biology,83(11–12): 607–612.

    Article  Google Scholar 

  • Beer, H.D., Gassmann, M.G., Munz, B.,et al. 2000. Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair [J]. J. Invest. Dermatol. Symp. Proc.,5(1): 34–39.

    Article  CAS  Google Scholar 

  • Boismenu, R. and Havran, W.L. 1994. Modulation of epithelial cell growth by intraepithelial γδT cells [J]. Science,266: 1253–1255.

    Article  PubMed  CAS  Google Scholar 

  • Braun, S., Hanselmann, C., Gassmann, M.G.,et al. 2002. Nrf-2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound [J]. Mol. Cell. Biol.,22: 5492–5505.

    Article  PubMed  CAS  Google Scholar 

  • Carrington, L.M. and Boulton, M. 2005. Hepatocyte growth factor and keratinocyte growth factor regulation of epithelial and stromal corneal wound healing [J]. Journal of Cataract & Refractive Surgery,31(2): 412–423.

    Article  Google Scholar 

  • Crescioli, C., Villari, D., Forti, G.,et al., 2002. Des (1–3) IGF-I-stimulated growth of human stromal BPH cells is inhibited by a vitamin D3 analogue [J]. Molecular and Cellular Endocrinology,198(1–2): 69–75.

    Article  PubMed  CAS  Google Scholar 

  • Dabelsteen, S., Christensen, S., Gron, B.,et al., 2005. HGF is released from buccal fibroblasts after smokeless tobacco stimulation [J]. Oral Oncology,41(5): 509–514.

    Article  PubMed  CAS  Google Scholar 

  • Dörr, W., Reichel, S. and Spekl, K. 2005. Effects of keratinocyte growth factor (palifermin) administration protocols on oral mucositis (mouse) induced by fractionated irradiation [J]. Radiotherapy and Oncology,75(1): 99–105.

    Article  PubMed  CAS  Google Scholar 

  • Farrell, C.L., Rex, K.L., Chen, J.N.,et al. 2002. The effects of keratinocyte growth factor in preclinical models of mucositis [J]. Cell. Prolif.,35(1): 78–85 (Supplement 1).

    Article  PubMed  CAS  Google Scholar 

  • Finch, P.W. and J.S. Rubin. 2004. Keratinocyte growth factor (KGF/FGF7), a homeostatic factor with therapeutic potential for epithelialprotection and repair [J]. Adv. cancer Res.,91: 69–136.

    PubMed  CAS  Google Scholar 

  • Finch P.W., Rubin J.S., Miki T.,et al. 1989. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth [J]. Science,245: 752–755.

    Article  PubMed  CAS  Google Scholar 

  • Galiacy, S., Planus, E., Lepetit, H.,et al., 2003. Keratinocyte growth factor promotes cell motility during alveolar epithelial repairin vitro [J]. Experimental Cell Research,283(2): 215–229.

    Article  PubMed  CAS  Google Scholar 

  • Gillis, P., Savla, U., Volpert, O.V.,et al., 1999 Keratinocyte growth factor induces angiogenesis and protects endothelial barrier function [J]. J. cell Sci.,112(Pt 12): 2049–2057.

    PubMed  CAS  Google Scholar 

  • Groves, R.W. and Schmidt-Lucke, J.A. 2000. Recombinant human GM-CSF in the treatment of poorly healing wounds [J]. Adv. Skin. Wound Care,13: 107–112.

    PubMed  CAS  Google Scholar 

  • Haddad, J.J. 2004. Redox and oxidant-mediated regulation of apoptosis signaling pathways: immuno-pharmaco-redox conception of oxidative siege versus cell death commitment [J]. International Immunopharmacology,4(4), 475–493.

    Article  PubMed  CAS  Google Scholar 

  • Hofmann, B., Hecht, H.J. and Flohe, L. 2002. Peroxiredoxins [J]. Biol. Chem.,383: 347–364.

    Article  PubMed  CAS  Google Scholar 

  • Hovey, R.C., Davey, H.W., Vonderhaar, B.K.,et al., 2001. Paracrine action of keratinocyte growth factor (KGF) during ruminant mammogenesis [J]. Molecular and Cellular Endocrinology,181(1–2): 47–56.

    Article  PubMed  CAS  Google Scholar 

  • Johnson D.E. and Williams, L.T. 1993. Structural and functional diversity in the FGF receptor multigene family [J]. Adv. Cancer. Res.,60: 1–41.

    Article  PubMed  CAS  Google Scholar 

  • Kamata, T., Hattori, Y., Hamada, H.,et al., 2002. Keratinocyte growth factor regulates proliferation and differentiation of hematopoietic cells expressing the receptor gene K-sam [J]. Experimental Hematology,30(4): 297–305.

    Article  PubMed  CAS  Google Scholar 

  • Kanzler, M.H., Gorsulowsky, D.C., and Swanson, N.A. 1986. Basic mechanisms in the healing cutaneouus wound [J]. J. Dermatol. Surg. Oncol.,12: 1156–1164.

    PubMed  CAS  Google Scholar 

  • Steenfos, H.H. 1994. Growth factors and wound healing [J]. Scand. J. Plast. Reconstr. Surg. Hand Surg.,28(2): 95–105.

    Article  PubMed  CAS  Google Scholar 

  • Karvinen, S., Pasonen-Seppanen, S., Hyttinen, J.M.,et al., 2003. Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3 [J]. J. Biol. Chem.,278(49): 495–504.

    Article  CAS  Google Scholar 

  • Koos, R.D., Banks, P.K., Inkster, S.E.,et al., 1993. Detection of aromatase and keratinocyte growth factor expression in breast tumors using reverse transcription-polymerase chain reaction [J]. Journal of Steroid Biochemistry and Molecular Biology,45(4): 217–225.

    Article  PubMed  CAS  Google Scholar 

  • Kopp, J., Wang, G.Y., Kulmburg, P.,et al., 2004. Accelerated Wound Healing by In vivo Application of Keratinocytes Overexpressing KGF [J]. Molecular Therapy,10(1): 86–96.

    Article  PubMed  CAS  Google Scholar 

  • Lin, M.P., Marti, G.P., Dieb, R.,et al., 2004. Electroporation improves transfection efficiency in rat wound healing model [J]. Journal of the American College of Surgeons,199(3): 58–59 (Supplement 1).

    Article  Google Scholar 

  • Marti, G.P., Lin, M.P., Qaiser, R.,et al., 2004. KGF-1 plasmid delivered with electroporation accelerates wound closure in diabetic mice [J]. Journal of the American College of Surgeons,199(3): 59 (Supplement 1).

    Article  Google Scholar 

  • Marti, G.P., Makary, M.A., Ferguson, M.,et al., 2004. Transfection with keratinocyte growth factor 1 cDNA with electroporation improves wounds healing in an aged mouse model [J]. Journal of Surgical Research,121(2): 320–321.

    Article  Google Scholar 

  • McGarvey, T.W. and Stearns, M.E. 1995. Keratinocyte Growth Factor and receptor mRNA expression in benign and malignant human prostate [J]. Experimental and Molecular Pathology,63(1), 52–62.

    Article  PubMed  CAS  Google Scholar 

  • Michelson, P.H., Tigue, M., Panos, R.J.,et al., 1999. Keratinocyte growth factor stimulates bronchial epithelia cell proliferationin vitro andin vivo [J]. Am. J. Physiol.,211(4 Pt 1): L737–742.

    Google Scholar 

  • Min, D., Taylor, P.A., Panoskaltsis-Mortari, A.,et al., 2002. Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation [J]. Blood,99: 4592–4600.

    Article  PubMed  CAS  Google Scholar 

  • Nguyen, T., Zang, X. and Pento, J.T. 2002. Keratinocyte growth factor stimulates the migration and proliferation of breast cancer cells in a culture wounding model [J]. Pharmacological Research,46(2): 179–183.

    Article  PubMed  CAS  Google Scholar 

  • Ornitz, D.M. and Itoh, N. 2001. Fibroblast growth factors [J]. Genome Biol. Reviews,2(3): 3005.1–3005.2.

    Google Scholar 

  • Ornitz, D.M., Xu, J., Colvin, J.S.,et al., 1996. Receptor specificity of the fibroblast growth factor family [J]. J. Biol. Chem.,271: 15292–15297.

    Article  PubMed  CAS  Google Scholar 

  • Panosm, R.J., Bak, P.M., Simonet, W.S.,et al. 1995. Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats [J]. J. Clin. Invest.,96: 2026–2033.

    Article  Google Scholar 

  • Parrott, J.A., Doraiswamy, V., Kim, G.,et al., 2001. Expression and actions of both the follicle stimulating hormone receptor and the luteinizing hormone receptor in normal ovarian surface epithelium and ovarian cancer [J]. Molecular and Cellular Endocrinology,172(1–2): 213–222.

    Article  PubMed  CAS  Google Scholar 

  • Parrott, J.A., Kim, G., Mosher, R.,et al., 2001. Expression and action of keratinocyte growth factor (KGF) in normal ovarian surface epithelium and ovarian cancer [J]. Molecular and Cellular Endocrinology,167(1–2): 77–87.

    Article  Google Scholar 

  • Ray, P., Devaux, Y., Stolz, D.B.,et al. 2003. Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia [J]. Proc. Natl. Acad. Sci USA.100: 6098–6103.

    Article  PubMed  CAS  Google Scholar 

  • Rossi, S., Blazar, B.R., Farrell, C.L.,et al., 2002. Keratinocyte growth factor preserves normal thymopoiesis and thymic microen- vironment during experimental graft-versus-host disease [J]. Blood,100: 682–691.

    Article  PubMed  CAS  Google Scholar 

  • Siddiqi, I., Funatomi, H., Kobrin, M.S.,et al., 1995. Increased expression of Keratinocyte Growth Factor in human pancreatic cancer [J]. Biochemical and Biophysical Research Communications,215(1): 309–315.

    Article  PubMed  CAS  Google Scholar 

  • Slonina, D., Hoinkis, C. and Dorr, W. 2001. Effect of keratinocyte growth factor on radiation survival and colony size of human epidermal keratinocytesin vitro [J]. Radiat. Res.,156(6): 761–766.

    Article  PubMed  CAS  Google Scholar 

  • Steiling, H., Wustefeld, T., Bugnon, P.,et al., 2003. Fibroblast growth factor receptor signalling is crucial for liver homeostasis and repair [J]. Oncogene,22: 4380–4388.

    Article  PubMed  CAS  Google Scholar 

  • Velagaleti, G.V.N., Tapper, J.K., Panova, N.E.,et al., 2003. Cytogenetic findings in a case of nodular fasciitis of subelavicular region [J]. Cancer Genetics and Cytogenetics,14(2): 160–163.

    Article  Google Scholar 

  • Wei, C., Chen, W., Wang, Y.,et al., 2005. Detection of IL-20 and its receptors on psoriatic skin [J]. Clinical Immunology,117(1): 65–72.

    Article  PubMed  CAS  Google Scholar 

  • Werner, S. and Smola, H. 2001. Paracrine regulation of keratinocyte proliferation and differentiation [J]. Trends in Cell Biology,11(4): 143–146.

    Article  PubMed  CAS  Google Scholar 

  • Werner, S., Peters, K.G., Longaker, M.T.,et al., 1992. Large induction of keratinocyte growth factor expression in the dermis during wound healing [J]. Proc. Natl Acad Sci U.S.A.89: 6896–6900.

    Article  PubMed  CAS  Google Scholar 

  • Wildhaber, B.E., Yang, H. and Teitelbaum, D.H. 2003. Total parenteral nutrition-induced apoptosis in mouse intestinal epithelium: modulation by keratinocyte growth factor [J]. Journal of Surgical Research,112(2): 144–151.

    Article  PubMed  CAS  Google Scholar 

  • Witte, R.P. and Kao, W.J. 2005. Keratinocyte-fibroblast paracrine interaction: the effects of substrate and culture condition [J]. Biomaterials,26(17): 3673–3682.

    Article  PubMed  CAS  Google Scholar 

  • Werner, S. 1998. Keratinocyte growth factor: a unique player in epithelial repair processes [J]. Cytokine Growth Factor Rev.,9(2): 153–165.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Genetics and Molecular Biology, College of Wildlife Resources, Northeast Forestry University, 150040, Harbin, China

    Zheng Wen-jing, Liu Xue-dong & Zheng Dong

  2. Laboratory of Genetics Resources, Institute of Animal Science, Chinese Academy of Agricultural Sciences, 100094, Beijing, China

    Liu Xue-dong & Zheng Dong

  3. School of Forestry, Northeast Forestry University, 150040, Harbin, China

    Yuan Li & Zheng Dong

Authors
  1. Zheng Wen-jing
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  2. Yuan Li
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  3. Liu Xue-dong
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  4. Zheng Dong
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Correspondence to Zheng Dong.

Additional information

Foundation item: This work was supported by the scientific scholarship of NEFU to D. ZHENG, the EYTIF fund of NEFU to X.LIU, and partial supported by the grant of the Ministration of Education (020-413229) to D. ZHENG.

Biography: ZHENG Wen-jing (1982-), female. Graduate of Physiology in College of Wildlife Resources, Northeast Forestry University, Harbin, 150040, China.

Responsible editor: Chai Ruihai

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Wen-jing, Z., Li, Y., Xue-dong, L. et al. Issues within Keratinocyte Growth Factor (KGF) research. Journal of Forestry Research 16, 335–338 (2005). https://doi.org/10.1007/BF02858203

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  • DOI: https://doi.org/10.1007/BF02858203

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