Abstract
The nucleophilic substitution reaction of 6-chloro purines (I) with malononitrile and ethyl cyanoacetate is carried out in DMSO and in the presence of an alkali. The possible tautomeric-ylidene form for the products is considered and discussed in view of IR, UV, NMR and mass spectral determinations. The derivatives were tested for their antitumor activities.
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Moharram, H.H., El-Bayouki, K.A.M., Haggag, B. et al. Synthesis and structure of purine derivatives as antitumor effects. Arch. Pharm. Res. 12, 138–142 (1989). https://doi.org/10.1007/BF02857738
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DOI: https://doi.org/10.1007/BF02857738