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Reactions of purine derivatives with phosphorus pentaoxide and triethylamine and their antitumor effects

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Abstract

6-Arylamino-3,7-dihydro-3,7-dimethy-2-oxo-1H-purine and 2-arylimino-6-arylamino-3,7-dihydro-3,7-dimethyl-1H-purine were obtained in a one-pot reaction when 3,7-dihydro-3,7-dimethyl-1H-purine-3,6-dione, phosphorus pentaoxide, triethylamine hydrochloride and appropriate amine amine are heated at 170°. Some derivatives were tested for their antitumor activity.

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Authors and Affiliations

  1. National Organisation For Drug Control and Research, P.O. Box 29, Cairo, Egypt

    H. H. Moharram & A. M. Osman

  2. Cancer Institute, Cairo University, Egypt

    H. H. Moharram & A. M. Osman

Authors
  1. H. H. Moharram
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  2. A. M. Osman
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Moharram, H.H., Osman, A.M. Reactions of purine derivatives with phosphorus pentaoxide and triethylamine and their antitumor effects. Arch. Pharm. Res. 12, 1–4 (1989). https://doi.org/10.1007/BF02855736

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  • DOI: https://doi.org/10.1007/BF02855736

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