Abstract
A simple, accurate and specific NMR procedure is described for the determination of ampicillin and cloxacillin mixtures in injection dosage form and capsules. The solvent was dimethylsulfoxde-d6 and maleic acid was the internal standard. By integrating the peak at 2.68 ppm and 4.57 ppm, cloxacillin and ampicillin could be determined respectively. The relative proton ratio of ampicillin trihydrate and cloxacillin were 1.038 and 0.950. The coefficents of variation of ampicillin trihydrate and cloxacillin in a few commercial preparation were 1.55% (n=9), 2.69% (n=15).
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Shin, MH., Park, MK., Yu, CH. et al. Determination of ampicillin and cloxacillin mixture by NMR. Arch. Pharm. Res. 4, 9–17 (1981). https://doi.org/10.1007/BF02856436
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DOI: https://doi.org/10.1007/BF02856436