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A pilot study of antitumor effect of gallium ethylenediaminetetramethylene phosphonate [Ga(III)-EDTMP] in tumor-bearing rats

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Abstract

The inhibitory effects of gallium ethylenediamine-N,N,N’,N’-tetrakismethylene phosphonate [Ga(III)-EDTMP] was studied on a malignant tumor and metastatic bone lesion model induced with Walker carcinosarcoma 256 (WCS 256) in Wistar rats weighing 120 to 135 g. A water-soluble chelate, Ga(III)-EDTMP, was prepared for injection in a tumor-bearing model. Radiographic analysis at 14 days indicated that the bone invasion and osteolysis were markedly reduced in animals treated with Ga(III)-EDTMP. The calculated tumor inhibitory rates were 33.16±0.38% at a dosage of 5 mg/kg and 47.75±0.74% at 10 mg/kg. Biochemical markers such as serum calcium decreased by 23% (P < .05) and by 31% (P < .01) at dosages of 5 mg/kg and 10 mg/kg, respectively, whereas serum alkaline phosphatase (ALPase) activity decreased by 47% (P < .01) and 69% (P < .01) at the 2 dosages.

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Authors and Affiliations

  1. School of Pharmacy, Shanghai JiaoTong University, 1954 Huashan Road, 200030, Shanghai, China

    Mingming Su MS, Yunping Qiu MS & Wei Jia PhD

  2. College of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China

    Mingming Su MS & Yunping Qiu MS

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  1. Mingming Su MS
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  2. Yunping Qiu MS
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  3. Wei Jia PhD
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Su, M., Qiu, Y. & Jia, W. A pilot study of antitumor effect of gallium ethylenediaminetetramethylene phosphonate [Ga(III)-EDTMP] in tumor-bearing rats. Adv Therapy 22, 297–306 (2005). https://doi.org/10.1007/BF02850079

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  • DOI: https://doi.org/10.1007/BF02850079

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