Abstract
The chiral aldol cylization of the prochiral triketone 3 using l-valine afforded the optically active compound 4 in high chemical and optical yield. The configuration and optical purity of (+)4 was determined by ORD, chemical resolution andnmr chirallsr studies. The title compound (+)7 was prepared from (+)4 following our earlier reported procedure.
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Banerjee, D.K., Kasturi, T.R. & Sarkar, A. Chiral synthesis of optically active S(+)-2,6,7,7a-tetrahydro-1β-hydroxy-4-formyl-7aβ-methylindene. Proc. Indian Acad. Sci. (Chem. Sci.) 92, 181–187 (1983). https://doi.org/10.1007/BF02840729
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DOI: https://doi.org/10.1007/BF02840729