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Induction of 2′,3′-cyclic nucleotide 3′-phosphohydrolase and morphological alterations in C6 glioma cells by dexamethasone, (3-butoxy-4-methoxybenzyl)-2-imidazolinone and prostaglandin E1

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Summary

Dexamethasone, R020-1724 and prostaglandin E1 all induced morphological alterations and increased the glial specific enzyme 2′,3′-cyclic nucleotide 3′-phosphohydrolase (CNP) in rat C6 glioma cells in culture. Morphological alterations consisted mainly in the development of astrocytelike changes. Increases in dexamethasone-induced CNP activity was time dependent. Dexamethasone reduced cell growth rate, depending on the concentration employed.

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Authors and Affiliations

  1. Department of Psychiatry, University of Iowa College of Medicine, 500 Newton Road, 52242, Iowa City, Iowa

    Rafiq Waziri & Shailendra K. Sahu

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  1. Rafiq Waziri
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  2. Shailendra K. Sahu
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This paper is supported in part by N.I.M.H. Research Grant AA02372. Dr. S. Kamath participated initially in this study.

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Waziri, R., Sahu, S.K. Induction of 2′,3′-cyclic nucleotide 3′-phosphohydrolase and morphological alterations in C6 glioma cells by dexamethasone, (3-butoxy-4-methoxybenzyl)-2-imidazolinone and prostaglandin E1 . In Vitro 16, 97–102 (1980). https://doi.org/10.1007/BF02831499

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  • DOI: https://doi.org/10.1007/BF02831499

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