Summary
Conclusion
We have described a case of pancreatic tumor formed by adult T-cell leukemia (ATL) cell infiltration.
Background
The patient was diagnosed as chronic ATL hematologically with the findings of increased number of atypical lymphocytes, ATL cells in the peripheral blood, and positive human T-cell leukemia virus type I (HTLV-I) antibody in the serum. The pancreatic tumor was identified by ultrasonography and computed tomography as a diffusely swollen tumor from the body to the tail of the pancreas. Biopsy specimen confirmed the ATL cell infiltration into the pancreas immunohistochemically, and Southern blot analysis showed the integration of HTLV-I proviral DNA both in the pancreas and in the peripheral blood.
Results
The pancreatic tumor diminished spontaneously without chemotherapy when ATL cells in the peripheral blood disappeared by spontaneous regression.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Wong-Staal F, Gallo RC. Human T-lymphotropic retroviruses.Nature 1985; 317: 395–403.
Hanada S, Uematsu T, Iwahashi M, Nomura K, Utsunomiya A, Kodama M, Ishibashi K, Terada A, Saito T, Makino T, Uozumi K, Kuwazuru Y, Otsuka M, Harada R, Hashimoto S, Sakurami T. The prevalence of human T-cell leukemia virus type I infection in patients with hematologic and nonhematologic diseases in an adult T-cell leukemia-endemic area of Japan.Cancer 1989; 64: 1290–1295.
Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H. Adult T-cell leukemia: clinical and hematological features of 16 cases.Blood 1977; 50: 481–492.
Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.Proc Natl Acad Sci USA 1980; 77: 7415–7419.
Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita KI, Shirakawa S, Miyoshi I. Antigen in an adult T-cell leukemia cell line and detection of antibodies to the antigen in human sera.Proc Natl Acad Sci USA 1981; 78: 6476–6480.
Kawano F, Yamaguchi K, Nishimura H, Tsuda H, Tatasuki K. Variation in the clinical courses of adult T-cell leukemia.Cancer 1985; 55: 851–856.
Sato E, Hasui K, Tokunaga M. Autopsy findings of adult T cell lymphoma-leukemia.Gann Monograph Cancer Res 1982; 28: 51–64.
Yamaguchi K, Nishimura H, Kohrogi H, Jono M, Miyamoto Y, Takatsuki K. A proposal for smoldering adult T-cell leukemia: a clinicopathologic study of five cases.Blood 1983; 62: 758–766.
Yoshioka R, Yamaguchi K, Yoshinaga T, Takatsuki K. Pulmonary complications in patients with adult T-cell leukemia.Cancer 1985; 55: 2491–2494.
Shimamoto Y, Kikuchi M, Funai N, Suga K, Matsuzaki M, Yamaguchi M. Spontaneous regression in adult T-cell leukemia/lymphoma.Cancer 1993; 72: 735–740.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mizumoto, K., Suehara, N., Ohuchida, J. et al. Pancreatic tumor formed by infiltration of adult T-cell leukemia cells. Int J Gastrointest Canc 21, 253–257 (1997). https://doi.org/10.1007/BF02821612
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02821612