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In vitro antimicrobial activity of 3,4-dihydro-s-triazinobenzimidazole derivatives

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Abstract

Among 31 3,4-dihydro-s-triazinobenzimidazole derivatives tested 12 compounds showedin vitro antimicrobial activity against G+ bacteria. Best results were obtained with substances containing naphthyl or halogenated phenyl group on the triazine ring. The tested derivatives had no significantin vitro antimicrobial activity against either the used G− species or fungi.

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References

  • Abdel-Rahman R.M., Seada M., El-Gendy Z., Islam I.E., Mahmoud M.N.: Synthesis of some new 4,6-disubstituted 1,2,4-triazin-3,5(2H)diones and related compounds of potential antifungal activity.Farmaco 48, 407–416 (1993).

    PubMed  CAS  Google Scholar 

  • Badawey E.A.M., Kappe T.: Synthesis andin vitro anti-HIV activity of certain 2-(1H-benzimidazol-2-ylamino)pyrimidin-4(3H)-ones and related derivates.Arch. Pharm. Pharm. Med. Chem. 330, 59–62 (1997).

    Article  CAS  Google Scholar 

  • Fekete-Forgács K., Gyüre L., Lenkey B.: Changes of virulence factors accompanying the phenomenon of induced fluconazole resistance inCandida albicans.Mycoses 43, 273–279 (2000).

    Article  PubMed  Google Scholar 

  • Holla B.S., Sarojini B.K., Gonsalves R.: Synthesis of some new biologically active thiadiazolotriazinones.Farmaco 53, 395–398 (1998).

    Article  PubMed  CAS  Google Scholar 

  • Jantová S., Greif G., Pavlovičová R., Čipák L.: Antibacterial effect of some 1-substituted 1,2,4-triazoles.Folia Microbiol. 43, 75–78 (1998).

    Article  Google Scholar 

  • Jantová S., Špirková K., Staňkovský S., Duchoňová P.: Antibacterial effect of some substituted tricyclic quinazolines and their synthetic precursors.Folia Microbiol. 43, 187–190 (1999).

    Article  Google Scholar 

  • Jantová S., Greif G., Špirková K., Staňkovský S., Oravcová M.: Antibacterial effect of trisubstituted quinazoline derivatives.Folia Microbiol. 45, 133–137 (2000).

    Google Scholar 

  • Martin D., Graubaum H., Kempter G., Ehrlichmann W.: Umsetzungen von 2-Guanidino-benzimidazol mit elektrophilen Reagentien.J. Prakt. Chem. 323, 303–310 (1981).

    Article  CAS  Google Scholar 

  • Nesměrák K., Pelouchová H., Všetečka V., Němec I., Gabriel J.: Antifungal effects of new heterocyclic compounds, 6H-pyrimido[2,1-a]isoindole derivatives.Folia Microbiol. 43, 39–43 (1998).

    Google Scholar 

  • Pócsi I., Sámi L., Letter É., Majoros L., Szabó B., Emri T., Pusztahelyi T.: Searching for new-type antifungal drugs.Acta Microbiol. Immunol. Hung. 48, 533–543 (2001).

    Article  PubMed  Google Scholar 

  • Serafin B., Borkowska G., Glowczyk J., Kovalska Y., Rump S.: Potential antihypertensive benzimidazole derivates.Polon. J. Pharmacol. Pharm. 41, 89–96 (1989).

    CAS  Google Scholar 

  • Strigáčová J., Hudecová D., Varečka L'., Lásiková A., Végh D.: Some biological properties of new quinoline-4-carboxylic acid and quinoline-4-carboxamide derivatives.Folia Microbiol. 45, 305–309 (2000).

    Google Scholar 

  • Neu H.C.: The crisis in antibiotic resistance.Science 257, 1064–1073 (1992).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Science, University of Debrecen, 4010, Debrecen, Hungary

    G. Gulyás & Z. Györgydeák

  2. Department of Microbiology and Biotechnology, Faculty of Science, University of Debrecen, 4010, Debrecen, Hungary

    T. Emri

  3. Department of Inorganic and Analytical Chemistry, Faculty of Science, University of Debrecen, 4010, Debrecen, Hungary

    A. Simon

Authors
  1. G. Gulyás
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  2. T. Emri
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  3. A. Simon
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  4. Z. Györgydeák
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Correspondence to Z. Györgydeák.

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Gulyás, G., Emri, T., Simon, A. et al. In vitro antimicrobial activity of 3,4-dihydro-s-triazinobenzimidazole derivatives. Folia Microbiol 47, 29–31 (2002). https://doi.org/10.1007/BF02818561

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  • DOI: https://doi.org/10.1007/BF02818561

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