Skip to main content
SpringerLink
Log in

Neuroimmunological findings in guillain barré syndrome, multiple sclerosis, and idiopathic polyneuropathies

  • Part XII Clinical and Experimental Investigations in the Caribbean
  • Published:
Molecular and chemical neuropathology

Abstract

It is essential to know how the immune system acts in different neurological diseases some of which are not very well known or are unknown.

IgG and albumin were simultaneously quantified in serum and cerebrospinal fluid (CSF) of 14 patients with Guillain Barré Syndrome (GSB), 5 patients with multiple sclerosis (MS), and 14 patients with idiopathic polyneuropathies (IP). IgG local synthesis was observed in all patients, except in patients with IP. These patients showed a decrease in cerebrospinal fluid (CSF) flow.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Andersson M., Alvarez-Cermeño J., Bernardi G., Cogato I., Fredman P., Frederiksen J., Fredrikson S., Gallo P., Grimaldi L. M., Gronning M., Keir G., Lamers K., Link H., Magalhaes A., Massarro A. R., Ohman S., Reiber H., Ronnaback L., Schlep M., Schuller E., Sindic C. J. M., Thompson E. J., Trojano M., and Wurster U. (1994) Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report.J. Neurol. Neurosurg. Psychiatry 57, 897–902.

    Article  CAS  Google Scholar 

  • Chutorian A. (1988) Chronic polyneuropathy in children.Int. Pediatr. 3, 125–131.

    Google Scholar 

  • Dorta A. J. (1995) Immune response in Cuban Epidemic Neuropathy.Mol. Chem. Neuropathol. 24, 263–266.

    Article  Google Scholar 

  • Dorta-Contreras A. J., García-Fernández L., and Gil-Chaviano M. (1991) Neuro-immunolab: sistema para la evaluación de la respuesta immune en el sistema nervioso central.Rev. Cubana Invest. Biomed. 10, 155.

    Google Scholar 

  • Ohman S., Ernerudh J., Forsberg P., Henriksson A., von Schenk H., and Vrethen M. (1992) Comparison of seven formulas and isoelectrofocusing for determination of intrathecally produced IgG in neurological diseases.Ann. Clin. Biochem. 29, 405–410.

    Article  Google Scholar 

  • OPS (1994) Neuropatía epidémica cubana. Una actualización.Bol. Epidemiol. OPS 15, 7.

    Google Scholar 

  • Parke J. T. (1990) Peripheral neuropathy, inPrinciples and Practice of Pediatrics (Oski F. A., De Angelis C. D., Feigin R. D., and Warshaw J. P., eds.), Lippincott, Philadelphia, pp. 1888–1893.

    Google Scholar 

  • Poser C. M., Paty D. W., and Scheinberg L. (1983) New diagnostic criteria for multiple sclerosis: Guidelines for research protocols.Ann. Neurol. 13, 227–231.

    Article  CAS  Google Scholar 

  • Reiber H. (1980) The discrimination between different blood-CSF barrier dysfunction and inflammatory reactions of the CNS by a recent evaluation graph for the protein profile of CSF.J. Neurol. 224, 89–99.

    Article  CAS  Google Scholar 

  • Reiber H. (1993) Decreased flow of cerebrospinal fluid (CSF) as origin of the pathological increase of protein concentration in CSF, inCNS Barriers and Modern CSF Diagnostics (Felgenhauer K., Holzgraefe M., and Prange H., eds.), VCH, Weinham, pp. 305–317.

    Google Scholar 

  • Reiber H. (1994a) Flow rate of cerebrospinal fluid (CSF)— a concept common to normal blood— CSF barrier function and to dysfunction in neurological diseases.J. Neurol. Sci. 122, 189–203.

    Article  CAS  Google Scholar 

  • Reiber H. (1994b) The hyperbolic function: a mathematical solution of the protein flux/CSF flow model for blood-CSF barrier function.J. Neurol. Sci. 126, 243–245.

    Article  Google Scholar 

  • Reiber H. and Felgenhauer K. (1987) Protein transfer at the blood spinal cerebro-spinal fluid and the quantitation of humoral immune response within the central nervous system.Clin. Chim. Acta. 13, 319–328.

    Article  Google Scholar 

  • Souverijn J. H. M., Serree H. M. P., Peet R., Grenzebach Smith W., and Bruyn G. W. (1991) Intrathecal immunoglobulin synthesis. Comparison of various formulae with the “gold standard” of isoelectric focusing.J. Neurol. Sci. 25, 152–161.

    Google Scholar 

  • Tourtellotte W. W. (1985) The cerebrospinal fluid, inAdvances in Multiple Sclerosis Research (Vinken P. F., ed.), Elsevier Science, New York, Chapter 47.

    Google Scholar 

  • Upton M. L. and Weller R. O. (1985) The morphology of cerebrospinal fluid drainage pathways in human arachnoid granulations.J. Neurosurg. 3, 867–875.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neuroimmunology Lab, Hospital Pediatrico, San Miguel, Apartado 10049, 11000, Ciudad de La Habana, Cuba

    Alberto Dorta-Contreras

  2. Hospital San Miguel, El Salvador, Centroamerica, USA

    René Silva-Somoza

Authors
  1. Alberto Dorta-Contreras
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. René Silva-Somoza
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dorta-Contreras, A., Silva-Somoza, R. Neuroimmunological findings in guillain barré syndrome, multiple sclerosis, and idiopathic polyneuropathies. Molecular and Chemical Neuropathology 28, 279–284 (1996). https://doi.org/10.1007/BF02815233

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02815233

Index Entries

Search

Navigation