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Monoclonal antibody affinities of structurally related modified nucleosides

  • Part XII Clinical and Experimental Investigations in the Caribbean
  • Published:
Molecular and chemical neuropathology

Abstract

A scale of relative affinities of a series of 2′-deoxycytidine and cytidine (CD) derivatives was established based on the data of cross-reactivities of these compounds as well as the displacements obtained from a competitive ELISA. No correlation could be established between the nucleosides modifying structures and the affinities. This can be explained by the possibilities of the modifying structures of intra- and intermolecular nonimmunospecific interactions owing to their degree of functionalization.

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Authors and Affiliations

  1. Molecular Biology Department, National Center for Scientific Research, 25th Ave #15202 & 158th St. Playa, PO Box 6880, Havana, Cuba

    David Higginson-Clarke, Rafael Guevara García, Adamaris López Brauet, Lilia López-Canovas & Ana Ma. Riverón Rojas

  2. Organic Chemistry Department, National Center for Scientific Research, 25th Ave #15202 & 158th St. Playa, PO Box 6880, Havana, Cuba

    Chryslaine Rodríguez Tanty & Arturo Macías Cabrera

Authors
  1. David Higginson-Clarke
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  2. Rafael Guevara García
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  3. Chryslaine Rodríguez Tanty
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  4. Adamaris López Brauet
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  5. Lilia López-Canovas
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  6. Ana Ma. Riverón Rojas
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  7. Arturo Macías Cabrera
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Higginson-Clarke, D., García, R.G., Tanty, C.R. et al. Monoclonal antibody affinities of structurally related modified nucleosides. Molecular and Chemical Neuropathology 28, 269–277 (1996). https://doi.org/10.1007/BF02815232

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  • DOI: https://doi.org/10.1007/BF02815232

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